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- 1From: Molecular Cancer. (Vol. 11) Peer-ReviewedBackground CADM1 encodes an immunoglobulin superfamily (IGSF) cell adhesion molecule. Inactivation of CADM1, either by promoter hypermethylation or loss of heterozygosity, has been reported in a wide variety of tumor...
- 2From: Molecular Cancer. (Vol. 11) Peer-ReviewedBackground Mantle cell lymphoma (MCL) is a well-defined aggressive lymphoid neoplasm characterized by proliferation of mature B-lymphocytes that have a remarkable tendency to disseminate. This tumor is considered as...
- 3From: Molecular Cancer. (Vol. 11) Peer-ReviewedBackground Metastatic melanoma is a devastating disease with limited therapeutic options. MicroRNAs (miRNAs) are small non coding RNA molecules with important roles in post-transcriptional gene expression regulation,...
- 4From: Molecular Cancer. (Vol. 11, Issue 1) Peer-ReviewedMultiple activations of individual genes during embryonic liver and HCC development have repeatedly prompted speculations about conserved embryonic signatures driving cancer development. Recently, the emerging...
- 5From: Molecular Cancer. (Vol. 11) Peer-ReviewedBackground We had previously demonstrated overexpression of fibroblast growth factor receptor-4 (FGFR4) in hepatocellular carcinoma (HCC). However, additional molecular mechanisms resulting in amplified FGFR4...
- 6From: Molecular Cancer. (Vol. 11, Issue 1) Peer-ReviewedBackground Tri- and tetra-nucleotide repeats in mammalian genomes can induce formation of alternative non-B DNA structures such as triplexes and guanine (G)-quadruplexes. These structures can induce mutagenesis,...
- 7From: Molecular Cancer. (Vol. 11, Issue 1) Peer-ReviewedBackground Hypermethylation of promotor CpG islands is a common mechanism that inactivates tumor suppressor genes in cancer. Genes belonging to the RASSF gene family have frequently been reported as epigenetically...
- 8From: Molecular Cancer. (Vol. 11, Issue 1) Peer-ReviewedBackground Colorectal cancer is one of the main cancers in the Western world. About 90% of the deaths arise from formation of distant metastasis. The expression of the newly identified gene metastasis associated in...
- 9From: Molecular Cancer. (Vol. 11, Issue 1) Peer-ReviewedBackground Lapatinib, a tyrosine kinase inhibitor of HER2 and EGFR and is approved, in combination with capecitabine, for the treatment of trastuzumab-refractory metastatic breast cancer. In order to establish a...
- 10From: Molecular Cancer. (Vol. 11, Issue 1) Peer-ReviewedBackground The membrane-bound mucins are thought to play an important biological role in cell-cell and cell-matrix interactions, in cell signaling and in modulating biological properties of cancer cell. MUC4, a...
- 11From: Molecular Cancer. (Vol. 11, Issue 1) Peer-ReviewedBackground Colorectal cancer is one of the most common malignant tumors worldwide. Loss of imprinting (LOI) of the insulin-like growth factor 2 (IGF2) gene is an epigenetic abnormality observed in human colorectal...
- 12From: Molecular Cancer. (Vol. 11, Issue 1) Peer-ReviewedAuthor(s): Ravi Mehrotra1 , Anurag Gupta2 , Mamta Singh3 and Rahela Ibrahim3 Retraction The authors would like to retract the article "Application of cytology and molecular biology in diagnosing premalignant or...
- 13From: Molecular Cancer. (Vol. 11, Issue 1) Peer-ReviewedBackground Rab proteins constitute a large family of monomeric GTP-binding proteins that regulate intracellular vesicle transport. Several Rab proteins, including rab31, have been shown to affect cancer progression...
- 14From: Molecular Cancer. (Vol. 11) Peer-ReviewedBackground Semaphorins act as chemotactic cues for cell movement via their transmembrane receptors, plexins. Somatic missense mutations in the plexinB1 gene coupled with overexpression of the protein frequently occur...
- 15From: Molecular Cancer. (Vol. 11, Issue 1) Peer-ReviewedBackground Induction of osteoblast differentiation by paracrine Sonic hedgehog (Shh) signaling may be a mechanism through which Shh-expressing prostate cancer cells initiate changes in the bone microenvironment and...
- 16From: Molecular Cancer. (Vol. 11, Issue 1) Peer-ReviewedBackground Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemias (Ph-positive ALL) with clinically approved inhibitors of the Bcr/Abl tyrosine kinase frequently results in the emergence of a...
- 17From: Molecular Cancer. (Vol. 11, Issue 1) Peer-ReviewedBackground In multiple myeloma (MM), the immunoglobulin heavy chain VDJ gene rearrangement is a unique clonotypic signature that identifies all members of the myeloma clone independent of morphology or phenotype....
- 18From: Molecular Cancer. (Vol. 11) Peer-ReviewedBackground Colorectal carcinomas (CRC) carry massive genetic and transcriptional alterations that influence multiple cellular pathways. The study of proteins whose loss-of-function (LOF) alters the growth of CRC...
- 19From: Molecular Cancer. (Vol. 11, Issue 1) Peer-ReviewedBackground Hepatocyte growth factor (HGF) induced c-Met activation is known as the main stimulus for hepatocyte proliferation and is essential for liver development and regeneration. Activation of HGF/c-Met signaling...
- 20From: Molecular Cancer. (Vol. 11) Peer-ReviewedBackground Carcinoma cells must circumvent the normally suppressive signals to disseminate. While often considered 'stop' signals for adherent cells, CXCR3-binding chemokines have recently been correlated positively...