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- 1From: BMC Bioinformatics. (Vol. 13) Peer-ReviewedBackground The epidermal growth factor receptor (EGFR) signaling pathway and angiogenesis in brain cancer act as an engine for tumor initiation, expansion and response to therapy. Since the existing literature does not...
- 2From: BMC Bioinformatics. (Vol. 17, Issue 164) Peer-ReviewedAuthor(s): Lu Cao1,4 , Marjo de Graauw2 , Kuan Yan1 , Leah Winkel3 and Fons J. Verbeek1 Background The epidermal growth factor receptor (EGFR) is important for normal growth and function of breast tissue. Its...
- 3From: BMC Bioinformatics. (Vol. 19, Issue 1) Peer-ReviewedBackground Some types of clinical genetic tests, such as cancer testing using circulating tumor DNA (ctDNA), require sensitive detection of known target mutations. However, conventional next-generation sequencing (NGS)...
- 4From: BMC Bioinformatics. (Vol. 20, Issue 1) Peer-ReviewedBackground The epidermal growth factor receptor (EGFR) is a major regulator of proliferation in tumor cells. Elevated expression levels of EGFR are associated with prognosis and clinical outcomes of patients in a...
- 5From: BMC Bioinformatics. (Vol. 24, Issue 1) Peer-ReviewedBackground Over the past several decades, metrics have been defined to assess the quality of various types of models and to compare their performance depending on their capacity to explain the variance found in...
- 6From: BMC Bioinformatics. (Vol. 20, Issue 1) Peer-ReviewedBackground Ontology has attracted substantial attention from both academia and industry. Handling uncertainty reasoning is important in researching ontology. For example, when a patient is suffering from cirrhosis, the...
- 7From: BMC Bioinformatics. (Vol. 20, Issue Suppl 2) Peer-ReviewedBackground Several methods to handle data generated from bottom-up proteomics via liquid chromatography-mass spectrometry, particularly for peptide-centric quantification dealing with post-translational modification...
- 8From: BMC Bioinformatics. (Vol. 20, Issue 1) Peer-ReviewedBackground Canonical correlation analysis (CCA) is a classic statistical tool for investigating complex multivariate data. Correspondingly, it has found many diverse applications, ranging from molecular biology and...
- 9From: BMC Bioinformatics. (Vol. 20, Issue 1) Peer-ReviewedBackground In the last few decades, cumulative experimental researches have witnessed and verified the important roles of microRNAs (miRNAs) in the development of human complex diseases. Benefitting from the rapid...
- 10From: BMC Bioinformatics. (Vol. 20, Issue 1) Peer-ReviewedBackground Many medical imaging techniques utilize fitting approaches for quantitative parameter estimation and analysis. Common examples are pharmacokinetic modeling in dynamic contrast-enhanced (DCE) magnetic...
- 11From: BMC Bioinformatics. (Vol. 20, Issue 1) Peer-ReviewedBackground Benefiting from big data, powerful computation and new algorithmic techniques, we have been witnessing the renaissance of deep learning, particularly the combination of natural language processing (NLP) and...
- 12From: BMC Bioinformatics. (Vol. 20, Issue 1) Peer-ReviewedBackground Although targeted drugs have contributed to impressive advances in the treatment of cancer patients, their clinical benefits on tumor therapies are greatly limited due to intrinsic and acquired resistance of...
- 13From: BMC Bioinformatics. (Vol. 20, Issue Suppl 24) Peer-ReviewedBackground Computational prediction of a phenotypic response upon the chemical perturbation on a biological system plays an important role in drug discovery, and many other applications. Chemical fingerprints are a...
- 14From: BMC Bioinformatics. (Vol. 21, Issue 1) Peer-ReviewedBackground In recent years, biomedical ontologies have become important for describing existing biological knowledge in the form of knowledge graphs. Data mining approaches that work with knowledge graphs have been...
- 15From: BMC Bioinformatics. (Vol. 21, Issue Suppl 2) Peer-ReviewedBackground In biomarker discovery, applying domain knowledge is an effective approach to eliminating false positive features, prioritizing functionally impactful markers and facilitating the interpretation of...
- 16From: BMC Bioinformatics. (Vol. 20, Issue 1) Peer-ReviewedBackground A large fraction of human and mouse autosomal genes are subject to random monoallelic expression (MAE), an epigenetic mechanism characterized by allele-specific gene expression that varies between clonal...
- 17From: BMC Bioinformatics. (Vol. 20, Issue Suppl 15) Peer-ReviewedBackground The Copy Number Alterations (CNAs) are discovered to be tightly associated with cancers, so accurately detecting them is one of the most important tasks in the cancer genomics. A series of CNAs detection...
- 18From: BMC Bioinformatics. (Vol. 20, Issue Suppl 9) Peer-ReviewedMotivation Current NGS techniques are becoming exponentially cheaper. As a result, there is an exponential growth of genomic data unfortunately not followed by an exponential growth of storage, leading to the necessity...
- 19From: BMC Bioinformatics. (Vol. 20, Issue 1) Peer-ReviewedBackground Feature selection, as a preprocessing stage, is a challenging problem in various sciences such as biology, engineering, computer science, and other fields. For this purpose, some studies have introduced...
- 20From: BMC Bioinformatics. (Vol. 20, Issue 1) Peer-ReviewedBackground Cryo-electron microscopy (cryo-EM) has become a widely used tool for determining the structures of proteins and macromolecular complexes. To acquire the input for single-particle cryo-EM reconstruction,...