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- 1From: Nature Reviews Nephrology. (Vol. 10, Issue 7) Peer-ReviewedPreoperative aspirin therapy could improve outcomes in patients with chronic kidney disease (CKD) undergoing cardiac surgery. Among 3,585 consecutive patients in two tertiary hospitals, 31.5% had CKD before cardiac...
- 2From: Nature Reviews Nephrology. (Vol. 10, Issue 7) Peer-ReviewedBlockade of sonic hedgehog protein (SHH) signalling is a plausible therapeutic strategy for renal fibrosis, say researchers. Expression of SHH was induced after renal injury in rodent models of chronic kidney disease...
- 3From: Nature Reviews Nephrology. (Vol. 10, Issue 7) Peer-ReviewedNew data from a prospective study suggest that serum levels of the immunoregulatory cytokine IL-10 are associated with increased risk of cardiovascular events in patients with chronic kidney disease (CKD). This finding...
- 4From: Nature Reviews Nephrology. (Vol. 10, Issue 7) Peer-ReviewedA reduction of salt intake to <5 g sodium chloride per day is generally advised for patients with chronic kidney disease. However, hard evidence to support this recommendation is lacking. New data from Fan et al....
- 5From: Nature Reviews Nephrology. (Vol. 10, Issue 7) Peer-ReviewedActivation of type 1 angiotensin (AT1) receptors on infiltrating macrophages might have antifibrotic effects. In mice subjected to unilateral ureteral obstruction, macrophage-specific AT1 receptor deficiency resulted in...
- 6From: Nature Reviews Nephrology. (Vol. 10, Issue 7) Peer-ReviewedIn the past 15 years, major advances have been made in understanding the role of lipids in podocyte biology. First, susceptibility to focal segmental glomerulosclerosis (FSGS) and glomerular disease is associated with...
- 7From: Nature Reviews Nephrology. (Vol. 10, Issue 7) Peer-ReviewedIn transplantation, the contribution of B cells to the rejection or acceptance of the allograft is a topic of major interest. The presence of donor-specific antibodies in transplant recipients is often associated with...
- 8From: Nature Reviews Nephrology. (Vol. 10, Issue 7) Peer-ReviewedHome peritoneal dialysis (PD) and home haemodialysis (HD) offer substantial advantages over in-centre HD for patients with end-stage kidney disease. Despite its benefits, a new study by Blair Grace at the University of...
- 9From: Nature Reviews Nephrology. (Vol. 10, Issue 7) Peer-ReviewedKidney transplant recipients who also receive a partial liver allograft have better long-term outcomes than those who receive a kidney alone, despite the more-complex surgery. Understanding how the liver exerts these...
- 10From: Nature Reviews Nephrology. (Vol. 10, Issue 7) Peer-ReviewedThe results of the POSEIDON trial (Prevention of Contrast Renal Injury with Different Hydration Strategies) have recently been reported. They show that a personalized hydration strategy--guided by intracardiac...
- 11From: Nature Reviews Nephrology. (Vol. 10, Issue 7) Peer-ReviewedA Canadian study has provided new data on the relationship between age, kidney function and risk of coronary events in patients with chronic kidney disease (CKD; n = 1,268,538). Regardless of CKD stage, the absolute...
- 12From: Nature Reviews Nephrology. (Vol. 10, Issue 7) Peer-ReviewedToll-like receptors (TLRs) and nucleotide-binding oligomerization domain receptors (NLRs) are families of pattern recognition receptors that, together with inflammasomes, sense and respond to highly conserved pathogen...
- 13From: Nature Reviews Nephrology. (Vol. 10, Issue 7) Peer-ReviewedSuppression of acute cellular alloimmunity, without eliciting adverse reactions, is vital to the overall outcome of kidney transplantation. New results from a phase II clinical trial represent an important step towards...
- 14From: Nature Reviews Nephrology. (Vol. 10, Issue 7) Peer-ReviewedNat. Rev. Nephrol. 10, 88-103 (2014); doi:10.1038/nrneph.2013.272 It is with regret that the editors of Nature Reviews Nephrology inform readers of the passing of Professor Michaela Diamant on 9 April 2014. Future...
- 15From: Nature Reviews Nephrology. (Vol. 10, Issue 7) Peer-ReviewedCells use an exquisite network of mechanisms to maintain the integrity and functionality of their protein components. In the endoplasmic reticulum (ER), these networks of protein homeostasis--referred to as...
- 16From: Nature Reviews Nephrology. (Vol. 10, Issue 7) Peer-ReviewedThe transcription factor Krueppel-like factor 4 (KLF4) promotes podocyte differentiation and protects against the development of proteinuria, say researchers. These new findings suggest that modulation of KLF4 might be...
- 17From: Nature Reviews Nephrology. (Vol. 10, Issue 7) Peer-ReviewedThe use of expanded-criteria donor kidneys demands careful assessment of the organ before and after transplantation to ensure patient benefit. However, histopathological analysis of pretransplant biopsy specimens is...
- 18From: Nature Reviews Nephrology. (Vol. 10, Issue 7) Peer-ReviewedSecondary analysis of the FAVORIT data in kidney transplant recipients showed that systolic blood pressure [greater than or equal to] 140 mmHg and diastolic blood pressure <70 mmHg at trial entry were associated with...
- 19From: Nature Reviews Nephrology. (Vol. 10, Issue 7) Peer-ReviewedThe effects of fetal development on kidney function are not well understood. However, two prospective studies by Vincent Jaddoe and colleagues have provided new insights into the impact of fetal blood flow and kidney...
- 20From: Nature Reviews Nephrology. (Vol. 10, Issue 7) Peer-ReviewedAn epidemic of chronic kidney disease (CKD) in Mesoamerica is providing new insights into the mechanisms by which salt and water might drive hypertension and CKD. Increasingly, evidence suggests that recurrent...