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- 1From: Nature Reviews Immunology. (Vol. 10, Issue 7) Peer-ReviewedMetastasis is the main cause of cancer-associated death and, therefore, it is important to determine when and how tumour cells disseminate from the primary tumour. It was previously thought that metastasis occurs late...
- 2From: Nature Reviews Immunology. (Vol. 10, Issue 7) Peer-ReviewedThis study identifies C/EBP[beta] as a crucial transcriptional regulator of the myeloid-derived suppressor cells (MDSCs) that are induced by, and suppress the immune response to, tumour cells. Bronte and colleagues...
- 3From: Nature Reviews Immunology. (Vol. 10, Issue 7) Peer-ReviewedThe cytokine interleukin-17 (IL-17) has received considerable attention since the discovery of a distinct [CD4.sup.+] T helper ([T.sub.H]) cell subset that produces it, known as the [T.sub.H]17 cell subset. Despite the...
- 4From: Nature Reviews Immunology. (Vol. 10, Issue 7) Peer-ReviewedThe enzyme sialic acid acetylesterase (SIAE) is a negative regulator of B cell receptor signalling, and mice with loss-of-function mutations in Siae develop an autoimmune syndrome. Previous genome-wide association...
- 5From: Nature Reviews Immunology. (Vol. 10, Issue 7) Peer-ReviewedMany viruses infect humans and most are controlled satisfactorily by the immune system with limited damage to host tissues. Some viruses, however, do cause overt damage to the host, either in isolated cases or as a...
- 6From: Nature Reviews Immunology. (Vol. 10, Issue 7) Peer-ReviewedFor goalkeepers playing in this month's World Cup, quick reactions are essential for stopping that ball from reaching the back of the net. Similarly, a rapid response by the innate immune system is crucial for...
- 7From: Nature Reviews Immunology. (Vol. 10, Issue 7) Peer-ReviewedNew research shows that the innate immune response to cytosolic viruses through retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) must be both rapid and sustained and that these properties are mediated by...
- 8From: Nature Reviews Immunology. (Vol. 10, Issue 7) Peer-Reviewed[gamma][delta] T cells have several innate cell-like features that allow their early activation following recognition of conserved stress-induced ligands. Here we review recent observations revealing the ability of...
- 9From: Nature Reviews Immunology. (Vol. 10, Issue 7) Peer-ReviewedTransforming growth factor-[beta] (TGF[beta]) is an important regulator of T cell tolerance, in part through the induction of regulatory T ([T.sub.Reg]) cells in the periphery. Now, a new study shows that it also...
- 10From: Nature Reviews Immunology. (Vol. 10, Issue 7) Peer-ReviewedMigrating cells adopt a polarized morphology, characterized by a leading-edge lamellipodia and a trailing-edge uropod, and move through tissues by sequential adhesion and release steps. Understanding the molecular...
- 11From: Nature Reviews Immunology. (Vol. 10, Issue 7) Peer-ReviewedHere the authors report that T cells can be reprogrammed as natural killer (NK)-like cells following deletion of B cell lymphoma 11b (Bclllb). BCL-11b is highly expressed by thymocytes from the double negative 2 (DN2)...
- 12From: Nature Reviews Immunology. (Vol. 10, Issue 7) Peer-ReviewedSystemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody (IgM, IgG and IgA)-containing immune complexes that are deposited in, and cause damage to, numerous organs--including the kidneys...
- 13From: Nature Reviews Immunology. (Vol. 10, Issue 7) Peer-ReviewedThe development of type 1 diabetes involves a complex interaction between pancreatic [beta]-cells and cells of both the innate and adaptive immune systems. Analyses of the interactions between natural killer (NK) cells,...
- 14From: Nature Reviews Immunology. (Vol. 10, Issue 7) Peer-ReviewedForkhead box P3 [(FOXP3).sup.+] regulatory T ([T.sub.Reg]) cells are potent mediators of dominant self tolerance in the periphery. But confusion as to the identity, stability and suppressive function of human...
- 15From: Nature Reviews Immunology. (Vol. 10, Issue 7) Peer-ReviewedThe incidence of sepsis (and death from septic shock) is increasing, and treatments are still inadequate. Now a study in Science offers promise for a new treatment option involving blockade of sphingosine kinase 1...
- 16From: Nature Reviews Immunology. (Vol. 10, Issue 7) Peer-ReviewedAcute viral infections are rapidly cleared by the host immune system, but there is evidence that depots of viral antigen can persist after the resolution of infection and sustain memory T cells. Previous studies...
- 17From: Nature Reviews Immunology. (Vol. 10, Issue 7) Peer-ReviewedThis Opinion article describes the newly discovered conserved immunological and structural features of the sequence-variable regions of HIV-1 gp120, which the authors suggest warrant the reappraisal of these regions as...
- 18From: Nature Reviews Immunology. (Vol. 10, Issue 7) Peer-ReviewedOne of the main challenges of developing an HIV-1 vaccine lies in eliciting immune responses that can overcome the antigenic variability exhibited by HIV. Most HIV-1 vaccine development has focused on inducing immunity...