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- 1From: Nature Neuroscience. (Vol. 10, Issue 7) Peer-ReviewedWe investigated the regulation of T-type channels by Rho-associated kinase (ROCK). Activation of ROCK via the endogenous ligand lysophosphatidic acid (LPA) reversibly inhibited the peak current amplitudes of rat...
- 2From: Nature Neuroscience. (Vol. 10, Issue 7) Peer-ReviewedWhen we talk about the stunning high note from the soprano at the opera or the deep sound of the bass at a jazz club, we use spatial concepts to describe sounds. These descriptors do not seem to be mere metaphors that...
- 3From: Nature Neuroscience. (Vol. 10, Issue 7) Peer-Reviewed
Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation.
Learning is accompanied by modulation of postsynaptic signal transocation pathways in neurons. Although the neuronal protein kinase cyclin-dependent kinase 5 (Cdk5) has been implicated in cognitive disorders, its role in... - 4From: Nature Neuroscience. (Vol. 10, Issue 7) Peer-ReviewedMaking Up the Mind By Chris Frith Blackwell, 2007 232 pp, paperback, $24.99 ISBN 1405160225 Perceiving the outside world and one's own actions in it might seem easy, at least when compared with trying to infer...
- 5From: Nature Neuroscience. (Vol. 10, Issue 7) Peer-ReviewedInhibition of another pyramidal cell. Inhibitory circuits in the neocortex used to be so simple. Although it's true that the neocortex has a mystifying assortment of inhibitory interneurons (1), most of the fast synaptic...
- 6From: Nature Neuroscience. (Vol. 10, Issue 7) Peer-ReviewedMutations in unc-46 in Caenorhabditis elegans cause defects in all behaviors that are mediated by GABA. Here we show that UNC-46 is a sorting lactar that localizes the vesicular GABA transporter to synaptic vesicles. The...
- 7From: Nature Neuroscience. (Vol. 10, Issue 7) Peer-ReviewedWe identified a mutation in Aats-gly (also known as gars or glycyl-tRNA synthetase), the Drosophila melanogasterortholog of the human GARS gene that is associated with Charcot-Marie-Tooth neuropathy type 2D (CMT2D), from...
- 8From: Nature Neuroscience. (Vol. 10, Issue 7) Peer-ReviewedTens of millions of portable mp3 players have sold in the past few years. We can now carry entire music collections in our pockets to entertain us while traveling or during long hours in laboratories and offices. These...
- 9From: Nature Neuroscience. (Vol. 10, Issue 7) Peer-ReviewedWe report that during cortical development in the mouse embryo, reversion-inducing cysteine-rich protein with Kazal motifs (RECK) critically regulates Notch signaling by antagonizing the ectodomain shedding of Notch...
- 10From: Nature Neuroscience. (Vol. 10, Issue 7) Peer-ReviewedTo the editor: Numerous studies report a negative eventrelated potential at occipito-temporal scalp sites between 130 and 200 ms (N170) that is larger when elicited by faces than by other object categories (1,2)....
- 11From: Nature Neuroscience. (Vol. 10, Issue 7) Peer-ReviewedMyelination in the peripheral nervous system requires close contact between Schwann cells and the axon, but the underlying molecular basis remains largely unknown. Here we show that cell adhesion molecules (CAMS) of the...
- 12From: Nature Neuroscience. (Vol. 10, Issue 7) Peer-ReviewedThe frequent occurrence of saccadic eye movements raises the question of how information is combined across separate glances into a stable, continuous percept. Here I show that visual form processing is altered at both...
- 13From: Nature Neuroscience. (Vol. 10, Issue 7) Peer-ReviewedTo the editor: The editors of Nature Neuroscience have taken a critical view (1) of my recent article (2) that discusses the long-standing scientific problems preventing human embryonic stem cells (hESCs) or their...
- 14From: Nature Neuroscience. (Vol. 10, Issue 7) Peer-ReviewedAmusia (commonly referred to as tone-deafness) is a difficulty in discriminating pitch changes in melodies that affects around 4% of the human population. Amusia cannot be explained as a simple sensory impairment. Here...
- 15From: Nature Neuroscience. (Vol. 10, Issue 7) Peer-ReviewedWe assessed the role of the human mirror neuron system (MNS) in complementary actions using functional magnetic resonance imaging while participants prepared to execute imitative or complementary actions. The BOLD signal...
- 16From: Nature Neuroscience. (Vol. 10, Issue 7) Peer-Reviewed
Is the N170 sensitive to the human face or to several intertwined perceptual and conceptual factors?
Reply: In our study (1), minimizing interstimulus perceptual variance (ISPV) eliminated N170 category effects, whereas ISPV differences modulated this component. Thus, previous studies on the N170 in which ISPV was not... - 17From: Nature Neuroscience. (Vol. 10, Issue 7) Peer-ReviewedAlthough endocannabinoids constitute one of the first lines of defense against pain, the anatomical locus and the precise receptor mechanisms underlying cannabinergic modulation of pain are uncertain. Clinical...
- 18From: Nature Neuroscience. (Vol. 10, Issue 7) Peer-ReviewedIn mammals, identifying the contribution of specific neurons or networks to behavior is a key challenge. Here we describe an approach that facilitates this process by enabling the rapid modulation of synaptic inhibition...
- 19From: Nature Neuroscience. (Vol. 10, Issue 7) Peer-ReviewedAlthough there is some neurogenesis in the adult brain, the vast majority of neurons are born during the embryonic period. What signals the end of this neurogenesis? This long-standing question generates intense interest...
- 20From: Nature Neuroscience. (Vol. 10, Issue 7) Peer-ReviewedThe polarity and adhesion of radial glial cells (RGCs), which function as progenitors and migrational guides for neurons, are critical for morphogenesis of the cerebral cortex. These characteristics largely depend on...