Showing Results for
- Academic Journals (7)
Search Results
- 7
Academic Journals
- 7
- Search Terms:
- 1From: The Pharmacogenomics Journal. (Vol. 10, Issue 6) Peer-ReviewedThere is great interest in characterizing the genetic architecture underlying drug response. For many drugs, gene-based dosing models explain a considerable amount of the overall variation in treatment outcome. As such,...
- 2From: The Pharmacogenomics Journal. (Vol. 10, Issue 6) Peer-ReviewedPublicly available genetic and expression data on lymphoblastoid cell lines (LCLs) make them a unique resource for understanding the genetic underpinnings of pharmacological outcomes and disease. LCLs have been used for...
- 3From: The Pharmacogenomics Journal. (Vol. 10, Issue 6) Peer-ReviewedThe dose of docetaxel is currently calculated based on body surface area and does not reflect the pharmacokinetic, metabolic potential or genetic background of the patients. The influence of genetic variation on the...
- 4From: The Pharmacogenomics Journal. (Vol. 10, Issue 6) Peer-ReviewedInter-individual variability in cytochrome P450 (CYP)-mediated xenobiotic metabolism is extensive. CYP1A2 is involved in the metabolism of drugs and in the bioactivation of carcinogens. The objective of this study was...
- 5From: The Pharmacogenomics Journal. (Vol. 10, Issue 6) Peer-ReviewedBecause angiotensin-converting enzyme (ACE) activity is implicated widely in biological systems, we aimed to identify its novel quantitative trait loci for the purposes of understanding ACE activity regulation and...
- 6From: The Pharmacogenomics Journal. (Vol. 10, Issue 6) Peer-ReviewedInduced expression of the Abcb1 drug transporter often occurs in tumors in response to chemotherapy. The role that epigenetic modifications within the ABCB1 promoter play in Abcb1 expression remains unclear. We selected...
- 7From: The Pharmacogenomics Journal. (Vol. 10, Issue 6) Peer-ReviewedTreatment of latent tuberculosis infection (LTBI) generally includes isoniazid (INH), a drug that can cause serious hepatotoxicity. Carboxylesterases (CES) are important in the metabolism of a variety of substrates,...