Showing Results for
- Academic Journals (21)
Search Results
- 21
Academic Journals
- 21
- Search Terms:
- 1From: Genes and Immunity. (Vol. 10, Issue 5) Peer-ReviewedOver 30 years ago, receptors for the Fc region of IgG (FcγR) were implicated in the pathogenesis of systemic lupus erythematosus (SLE). Since those pioneering studies, our knowledge of the structure and function of these...
- 2From: Genes and Immunity. (Vol. 10, Issue 5) Peer-ReviewedTNFAIP3 encodes the ubiquitin-modifying enzyme, A20, a key regulator of inflammatory signaling pathways. We previously reported association between TNFAIP3 variants and systemic lupus erythematosus (SLE). To further...
- 3From: Genes and Immunity. (Vol. 10, Issue 5) Peer-ReviewedOsteopontin (OPN) is a multifunctional cytokine involved in long bone remodeling and immune system signaling. Additionally, OPN is critical for interferon-α (IFN-α) production in murine plasmacytoid dendritic cells. We...
- 4From: Genes and Immunity. (Vol. 10, Issue 5) Peer-ReviewedIn our earlier study, we utilized a Bayesian design to probe the association of ~1000 genes (~10000 single-nucleotide polymorphisms (SNPs)) with systemic lupus erythematosus (SLE) on a moderate number of trios of parents...
- 5From: Genes and Immunity. (Vol. 10, Issue 5) Peer-ReviewedWe targeted LYN, a src-tyosine kinase involved in B-cell activation, in case-control association studies using populations of European-American, African-American and Korean subjects. Our combined European-derived...
- 6From: Genes and Immunity. (Vol. 10, Issue 5) Peer-ReviewedAlthough the etiology of systemic lupus erythematosus (SLE) remains to be fully elucidated, it is now apparent that multiple genetic and environmental factors are at play. Over the past decade, several studies have...
- 7From: Genes and Immunity. (Vol. 10, Issue 5) Peer-ReviewedWomen develop chronic inflammatory autoimmune diseases more often than men. The mechanisms causing the increased susceptibility are incompletely understood. Chronic immune stimulation characterizes many autoimmune...
- 8From: Genes and Immunity. (Vol. 10, Issue 5) Peer-ReviewedThere have been many genetic studies of systemic lupus erythematosus (SLE) in Asia, but the status of SLE in Asia remains unclear. Genes that have been associated with SLE in Caucasians have shown both consistent and...
- 9From: Genes and Immunity. (Vol. 10, Issue 5) Peer-ReviewedThe aim of this study was to perform a meta-analysis of the association between the factor V Leiden polymorphism (FVL) and thrombosis among patients with systemic lupus erythematosus (SLE) and/or antiphospholipid...
- 10From: Genes and Immunity. (Vol. 10, Issue 5) Peer-ReviewedGenetic variation was first shown to be important in systemic lupus erythematosus (SLE or lupus) in the 1970s with associations in the human leukocyte antigen region. Almost four decades later, and with the help of...
- 11From: Genes and Immunity. (Vol. 10, Issue 5) Peer-ReviewedSystemic lupus erythematosus (SLE) is a complex autoimmune disease. Genome-wide linkage studies implicated a region containing the adhesion molecule P-Selectin. This family-based study revealed two regions of association...
- 12From: Genes and Immunity. (Vol. 10, Issue 5) Peer-ReviewedComplete deficiency of complement C4 is among the strongest genetic risk factors for human systemic lupus erythematosus (SLE). C4 is a constituent of the RP-C4-CYP21-TNX (RCCX) module in the human leukocyte antigen (HLA)...
- 13From: Genes and Immunity. (Vol. 10, Issue 5) Peer-ReviewedComplement cascade plasma proteins play a complex role in the etiopathogenesis of systemic lupus erythematosus (SLE). Hereditary C1q deficiency has been strongly related to SLE, however, there are very few published SLE...
- 14From: Genes and Immunity. (Vol. 10, Issue 5) Peer-ReviewedSystemic Lupus Erythematosus (SLE) disproportionately affects minorities, such as Hispanic Americans (HA). Prevalence of SLE is 3-5 times higher in HA than in European-derived populations and have more active disease at...
- 15From: Genes and Immunity. (Vol. 10, Issue 5) Peer-ReviewedSystemic lupus erythematosus (SLE) disproportionately affects women. Recent work demonstrates that men with Klinefelter's syndrome (47,XXY men) have a similar risk of developing SLE as do women. We present an unusual...
- 16From: Genes and Immunity. (Vol. 10, Issue 5) Peer-ReviewedSle3 is a NZM2410/NZW-derived lupus-susceptibility interval on murine chromosome 7, which is associated with spontaneous lupus nephritis (SLN), and also anti-GBM-induced glomerulonephritis (GN). The tissue kallikrein...
- 17From: Genes and Immunity. (Vol. 10, Issue 5) Peer-ReviewedAs the central component of the complement system, C3 has sensory and effector functions bridging innate and adaptive immunity. It is plausible that common genetic variation at C3 determines either serum C3 level or...
- 18From: Genes and Immunity. (Vol. 10, Issue 5) Peer-ReviewedSystemic lupus erythematosus (SLE) is an autoimmune disease with highly variable clinical presentation. Patients suffer from immunological abnormalities that target T-cell, B-cell and accessory cell functions. B cells...
- 19From: Genes and Immunity. (Vol. 10, Issue 5) Peer-ReviewedThe CDKN1A gene encoding a cell cycle inhibitor, p21(WAF1/CIP1), is located in the systemic lupus erythematosus (SLE) susceptibility locus on chromosome 6p21.2. Decreased cellular levels of p21 are associated with SLE...
- 20From: Genes and Immunity. (Vol. 10, Issue 5) Peer-ReviewedGenetic factors influence susceptibility to systemic lupus erythematosus (SLE). A recent family-based analysis in Caucasian and Chinese populations provided evidence for association of single-nucleotide polymorphisms...