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- Search Terms:ISSN: 1553734XAndISSN: 15537358AndVolume Number: 10AndIssue Number: 3AndStart Page: e1003533AndDate: 2014 Revise Search
- 1From: PLoS Computational Biology. (Vol. 10, Issue 3) Peer-ReviewedThe liver is the central organ for detoxification of xenobiotics in the body. In pharmacokinetic modeling, hepatic metabolization capacity is typically quantified as hepatic clearance computed as degradation in...
- 2From: PLoS Computational Biology. (Vol. 10, Issue 3) Peer-ReviewedThe macaque brain serves as a model for the human brain, but its suitability is challenged by unique human features, including connectivity reconfigurations, which emerged during primate evolution. We perform a...
- 3From: PLoS Computational Biology. (Vol. 10, Issue 3) Peer-ReviewedModeling a gene's expression from its intergenic locus and trans-regulatory context is a fundamental goal in computational biology. Owing to the distributed nature of cis-regulatory information and the poorly understood...
- 4From: PLoS Computational Biology. (Vol. 10, Issue 3) Peer-ReviewedIn order to attempt to understand the complexity inherent in nature, mathematical, statistical and computational techniques are increasingly being employed in the life sciences. In particular, the use and development of...
- 5From: PLoS Computational Biology. (Vol. 10, Issue 3) Peer-ReviewedPredicting the dynamic behavior of a large network from that of the composing modules is a central problem in systems and synthetic biology. Yet, this predictive ability is still largely missing because modules display...
- 6From: PLoS Computational Biology. (Vol. 10, Issue 3) Peer-ReviewedThe voltage trace of neuronal activities can follow multiple timescale dynamics that arise from correlated membrane conductances. Such processes can result in power-law behavior in which the membrane voltage cannot be...
- 7From: PLoS Computational Biology. (Vol. 10, Issue 3) Peer-ReviewedAbsence epilepsy is believed to be associated with the abnormal interactions between the cerebral cortex and thalamus. Besides the direct coupling, anatomical evidence indicates that the cerebral cortex and thalamus...
- 8From: PLoS Computational Biology. (Vol. 10, Issue 3) Peer-ReviewedIn order to cross a street without being run over, we need to be able to extract very fast hidden causes of dynamically changing multi-modal sensory stimuli, and to predict their future evolution. We show here that a...
- 9From: PLoS Computational Biology. (Vol. 10, Issue 3) Peer-ReviewedThe evolution of ever increasing complex life forms has required innovations at the molecular level in order to overcome existing barriers. For example, evolving processes for cell differentiation, such as epigenetic...
- 10From: PLoS Computational Biology. (Vol. 10, Issue 3) Peer-ReviewedHow the Lab Started Start of the lab: 2006 Size of the lab: Currently ten--size has fluctuated between five and 20 Research field: Systems and synthetic biology In 2005, I was working in the bioinformatics...
- 11From: PLoS Computational Biology. (Vol. 10, Issue 3) Peer-ReviewedDiscovery in developmental biology is often driven by intuition that relies on the integration of multiple types of data such as fluorescent images, phenotypes, and the outcomes of biochemical assays. Mathematical...
- 12From: PLoS Computational Biology. (Vol. 10, Issue 3) Peer-ReviewedThe transcription factor nuclear factor kappa-B (NF[kappa]B) is a key regulator of pro-inflammatory and pro-proliferative processes. Accordingly, uncontrolled NF[kappa]B activity may contribute to the development of...
- 13From: PLoS Computational Biology. (Vol. 10, Issue 3) Peer-ReviewedVast research efforts have been devoted to providing clinical diagnostic markers of myocardial infarction (MI), leading to over one million abstracts associated with "MI" and "Cardiovascular Diseases" in PubMed....
- 14From: PLoS Computational Biology. (Vol. 10, Issue 3) Peer-ReviewedIt is a long-established fact that neuronal plasticity occupies the central role in generating neural function and computation. Nevertheless, no unifying account exists of how neurons in a recurrent cortical network...
- 15From: PLoS Computational Biology. (Vol. 10, Issue 3) Peer-ReviewedBiological protein interactions networks such as signal transduction or gene transcription networks are often treated as modular, allowing motifs to be analyzed in isolation from the rest of the network. Modularity is...
- 16From: PLoS Computational Biology. (Vol. 10, Issue 3) Peer-ReviewedThe continuously prolonged human lifespan is accompanied by increase in neurodegenerative diseases incidence, calling for the development of inexpensive blood-based diagnostics. Analyzing blood cell transcripts by...
- 17From: PLoS Computational Biology. (Vol. 10, Issue 3) Peer-ReviewedThe prospect of using whole genome sequence data to investigate bacterial disease outbreaks has been keenly anticipated in many quarters, and the large-scale collection and sequencing of isolates from cases is becoming...
- 18From: PLoS Computational Biology. (Vol. 10, Issue 3) Peer-ReviewedSequence-based protein homology detection has been extensively studied and so far the most sensitive method is based upon comparison of protein sequence profiles, which are derived from multiple sequence alignment (MSA)...
- 19From: PLoS Computational Biology. (Vol. 10, Issue 3) Peer-ReviewedExchanging ideas with like-minded, enthusiastic people interested in the same topic is crucial for the advancement of a scientist's career. Several Regional Student Groups (RSGs) of the International Society for...
- 20From: PLoS Computational Biology. (Vol. 10, Issue 3) Peer-ReviewedAs the more recent next-generation sequencing (NGS) technologies provide longer read sequences, the use of sequencing datasets for complete haplotype phasing is fast becoming a reality, allowing haplotype reconstruction...