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- 1From: Nature Reviews Cancer. (Vol. 10, Issue 12) Peer-ReviewedKRAS mutations are common in cancers, but oncogenic KRAS has differing effects--in some cases, it induces hyperproliferation, whereas in others it leads to senescence. A recent study has identified the transcription...
- 2From: Nature Reviews Cancer. (Vol. 10, Issue 12) Peer-ReviewedThe second messenger cyclic AMP (cAMP) has a key role in numerous cellular processes. In response to melanocyte-stimulating hormone (MSH) cAMP enhances skin pigmentation and protects against ultraviolet (UV)-induced...
- 3From: Nature Reviews Cancer. (Vol. 10, Issue 12) Peer-ReviewedLarge numbers of inhibitors for polo-like kinases and aurora kinases are currently being evaluated as anticancer drugs. Interest in these drugs is fuelled by the idea that these kinases have unique functions in mitosis....
- 4From: Nature Reviews Cancer. (Vol. 10, Issue 12) Peer-ReviewedMelo, S. et al. Cancer Cell 18, 303-315 (2010) A key step in the maturation of microRNAs (miRNAs) is the nucleocytoplasmic export through exportin 5 (XPO5) of the pre-miRNAs. Melo et al. have found mutations in XPO5...
- 5From: Nature Reviews Cancer. (Vol. 10, Issue 12) Peer-ReviewedThe importance of apoptosis as a tumour suppressive mechanism is well documented, especially in the haematopoietic system, but which components of the apoptotic pathway, through either their gain or their loss of...
- 6From: Nature Reviews Cancer. (Vol. 10, Issue 12) Peer-ReviewedAberrant vascularity in tumours results in hypoxic tumour regions that are distant from blood vessels, as oxygen is poorly delivered to these areas. As drugs are also not efficiently delivered in these circumstances,...
- 7From: Nature Reviews Cancer. (Vol. 10, Issue 12) Peer-ReviewedThe increasing number of cancer survivors is cause for celebration, but this expanding population has highlighted the problem of tumour dormancy, which can lead to relapse. As we start to understand more about the...
- 8From: Nature Reviews Cancer. (Vol. 10, Issue 12) Peer-ReviewedGuo, Z. et al. Science 330, 517-521 (2010) Cells that are deficient for the tumour-suppressive kinase ataxia-telangiectasia mutated (ATM) are sensitive to oxidative-induced stress and DNA double-strand breaks (DSBs)....
- 9From: Nature Reviews Cancer. (Vol. 10, Issue 12) Peer-ReviewedGilbert, L. A. & Hemann, M. T Cell 143, 355-366 (2010) This study indicates that the tumour microenvironment has a role in chemotherapeutic responses. In a mouse model of Burkitt's lymphoma, administration of a...
- 10From: Nature Reviews Cancer. (Vol. 10, Issue 12) Peer-ReviewedA recent paper published in Cell extends the current understanding of how ligand-mediated activation of epidermal growth factor receptors (EGFRs) is regulated by showing that a cytoplasmic family of proteins known as...
- 11From: Nature Reviews Cancer. (Vol. 10, Issue 12) Peer-ReviewedThere is now considerable and increasing evidence for a causal role for aberrant activity of the Ras superfamily of small GTPases in human cancers. These GTPases function as GDP-GTP-regulated binary switches that...
- 12From: Nature Reviews Cancer. (Vol. 10, Issue 12) Peer-ReviewedThe involvement of the p53 family member p63 in tumour suppression and in promoting tumorigenesis has been a matter of debate, and a new paper in Nature now clarifies the tumour suppressor function of p63. The...
- 13From: Nature Reviews Cancer. (Vol. 10, Issue 12) Peer-ReviewedJay S. Desgrosellier & David A. Cheresh Nature Reviews Cancer 10, 9-22 (2010) On page 17 of this article, in the section Targeting [alpha]v[beta]3 and [alpha]v[beta]5 the sentence at the start of the second...
- 14From: Nature Reviews Cancer. (Vol. 10, Issue 12) Peer-ReviewedA small proportion of non-small-cell lung cancers (between 2% and 7%) have a chromosomal translocation that results in the fusion of echinoderm microtubule-associated protein-like kinase 4 (EML4) with anaplastic...
- 15From: Nature Reviews Cancer. (Vol. 10, Issue 12) Peer-ReviewedPortela, M. et al. Dev. Cell 19, 562-573 (2010) Cell competition is important for eliminating suboptimal cells during development and might also have a role in cancer. A physiological mechanism that counteracts cell...
- 16From: Nature Reviews Cancer. (Vol. 10, Issue 12) Peer-ReviewedCurrent evidence highlights the ability of adaptor (or scaffold) proteins to create signalling platforms that drive cellular transformation upon integrin-dependent adhesion and growth factor receptor activation. The...
- 17From: Nature Reviews Cancer. (Vol. 10, Issue 12) Peer-ReviewedThe family of protein deacetylases represented by yeast Sir2 has been the focus of intense investigation because of the longevity activity of Sir2 in yeast, worms and flies. Research in mammals has mainly focused on...
- 18From: Nature Reviews Cancer. (Vol. 10, Issue 12) Peer-ReviewedTanaka, H. et al. Nature Med. 7 Oct 2010 (doi:10.1038/nm.2236) These authors compared gene expression signatures from isogenic xenografts of androgen-dependent and castration-resistant prostate cancer. They...
- 19From: Nature Reviews Cancer. (Vol. 10, Issue 12) Peer-ReviewedYes-associated protein (YAP) is a transcriptional co-activator that shuttles between the cytoplasm and the nucleus. The role of YAP-mediated gene expression in tumorigenesis is unclear, as there are reports that YAP has...
- 20From: Nature Reviews Cancer. (Vol. 10, Issue 12) Peer-ReviewedHall, C. A. et al. Cancer Res. 70, 8517-8525 (2010) The transcriptional co-activator YAP shuttles between the cytoplasm and the nucleus and is part of the Hippo tumour suppressor pathway. Recent data have implied...