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- 1From: Nature Immunology. (Vol. 10, Issue 10) Peer-ReviewedIn the beginning of 2009, President Obama's decision to overturn a ban on federal funding for embryonic stem cell research was received with great enthusiasm by the scientific community. Although research in the field...
- 2From: Nature Immunology. (Vol. 10, Issue 10) Peer-ReviewedThe transcription factor Foxp3 represses the expression of select proinflammatory genes in [T.sub.reg] cells. In Science, Pardoll and co-workers find that the zinc-finger Ikaros family transcription factor Eos is...
- 3From: Nature Immunology. (Vol. 10, Issue 10) Peer-ReviewedSignals through the pre-B cell antigen receptor (pre-BCR) and interleukin 7 receptor (IL-7R) coordinate pre-B cell population expansion with subsequent recombination of the locus encoding immunoglobulin κ-chain (Igk)....
- 4From: Nature Immunology. (Vol. 10, Issue 10) Peer-ReviewedCysteine is an essential amino acid, yet naive T cells are unable to efficiently use its more abundant oxidized form, cystine. In Nature Chemical Biology, Banerjee and colleagues report that dendritic cell (DC)...
- 5From: Nature Immunology. (Vol. 10, Issue 10) Peer-ReviewedEven in organs such as the thymus, in which large numbers of cells die at developmental checkpoints, apoptotic cells are rapidly cleared by phagocytosis. In Nature, Ravichandran and co-workers identify a chemoattractant...
- 6From: Nature Immunology. (Vol. 10, Issue 10) Peer-ReviewedMore than 20 years after the first successful engraftment of human leukocytes and hematopoietic organs in mice, scientists met for the 2nd International Workshop on Humanized Mice to discuss progress and to highlight...
- 7From: Nature Immunology. (Vol. 10, Issue 10) Peer-ReviewedRNA is sensed by Toll-like receptor 7 (TLR7) and TLR8 or by the RNA helicases LGP2, Mda5 and RIG-I to trigger antiviral responses. Much less is known about sensors for DNA. Here we identify a novel DNA-sensing pathway...
- 8From: Nature Immunology. (Vol. 10, Issue 10) Peer-ReviewedCytosolic DNA sensors have remained poorly defined so far. Two recent studies identify a previously undefined cytosolic DNA-sensing pathway that depends on the RNA polymerase III-mediated conversion of microbial DNA into...
- 9From: Nature Immunology. (Vol. 10, Issue 10) Peer-ReviewedNod2 is a cytoplasmic Nod-like receptor protein that detects the peptidoglycan subfragment muramyl dipeptide. New work shows that Nod2 also has an important role in recognizing viruses and in triggering interferon...
- 10From: Nature Immunology. (Vol. 10, Issue 10) Peer-ReviewedPattern-recognition receptors (PRRs), including Toll-like receptors (TLRs) and RIG-like helicase (RLH) receptors, are involved in innate immune antiviral responses. Here we show that nucleotide-binding oligomerization...
- 11From: Nature Immunology. (Vol. 10, Issue 10) Peer-ReviewedImmunoglobulin secretion is modulated by competition between the use of a weak promoter-proximal poly(A) site and a nonconsensus splice site in the final secretory-specific exon of the heavy chain pre-mRNA. The RNA...
- 12From: Nature Immunology. (Vol. 10, Issue 10) Peer-ReviewedThe Science Gallery, Trinity College Dublin, recently held an exhibition called "INFECTIOUS: STAY AWAY" that used art to illustrate infection and immunity. Luke O'Neill talks to one of the artists, Gordana Novakovic,...
- 13From: Nature Immunology. (Vol. 10, Issue 10) Peer-ReviewedToll-like receptors (TLRs) are pivotal in innate immunity and inflammation. Here we show that genetic deficiency in Peli1, an E3 ubiquitin ligase, attenuated the induction of proinflammatory cytokines by ligands of TLR3...
- 14From: Nature Immunology. (Vol. 10, Issue 10) Peer-ReviewedNatural killer (NK) cells are a subset of lymphocytes crucial for innate immunity and modification of adaptive immune responses. In contrast to commitment to the T cell or B cell lineage, little is known about NK cell...
- 15From: Nature Immunology. (Vol. 10, Issue 10) Peer-ReviewedMst1 is a protein kinase essential for clustering of the integrin LFA-1, cell polarization and adhesion induced by Rap1-RAPL. In the Journal of Immunology, Dong et al. show that Mst1 has a cell-intrinsic role in...
- 16From: Nature Immunology. (Vol. 10, Issue 10) Peer-ReviewedA screen for increased longevity in Caenorhabditis elegans has identified a transcription factor that programs cells for resistance to oxidative stress, DNA repair and cell cycle control. The mammalian orthologs of this...
- 17From: Nature Immunology. (Vol. 10, Issue 10) Peer-ReviewedThe cytosolic protein RIG-I is best known as an intracellular viral sensor that triggers the expression of interferon and proinflammatory genes. In Cell Host & Microbe, Kong et al. show that RIG-I acts together with...
- 18From: Nature Immunology. (Vol. 10, Issue 10) Peer-ReviewedInterleukin 17 (IL-17)-producing [CD4.sup.+] helper T cells ([T.sub.H]-17 cells) share a developmental relationship with [Foxp3.sup.+] regulatory T cells ([T.sub.reg] cells). Here we show that a [T.sub.H]-17 population...
- 19From: Nature Immunology. (Vol. 10, Issue 10) Peer-ReviewedCeliac disease driven by an antigluten T cell response is strongly associated with the histocompatibility antigen HLA- DQ2.5 but is barely associated with HLA-DQ2.2. Yet these molecules have very similar peptide-binding...
- 20From: Nature Immunology. (Vol. 10, Issue 10) Peer-ReviewedTranscription factors are critical regulators of cell fate in the hemato-lymphoid system. New evidence indicates that the basic leucine zipper transcription factor E4BP4 (also known as NFIL3) is essential for natural...