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- 1From: Nature Reviews Cancer. (Vol. 10, Issue 10) Peer-ReviewedKedde, M. et al. Nature Cell Biol. 5 Sep 2010 (doi: 10.1038/ncb2105) MicroRNAs (miRNAs) and RNA-binding proteins (RBPs) interact with 3' untranslated regions (3' UTRs) to regulate gene expression. Reuven Agami and...
- 2From: Nature Reviews Cancer. (Vol. 10, Issue 10) Peer-ReviewedThe 'guardian of the genome', p53, is a crucial defence against cancer and viral replication, and is inactivated in most cancers. Human adenoviruses produce the protein E1B-55K, which leads to p53 degradation and...
- 3From: Nature Reviews Cancer. (Vol. 10, Issue 10) Peer-ReviewedRecently, it has become possible to mobilize the Tcl/mariner transposon, Sleeping Beauty (SB), in mouse somatic cells at frequencies high enough to induce cancer. Tumours result from SB insertional mutagenesis of cancer...
- 4From: Nature Reviews Cancer. (Vol. 10, Issue 10) Peer-ReviewedEpithelial to mesenchymal transition (EMT) is an essential and highly regulated process that occurs during embryogenesis and wound healing, and is also induced during tumour metastasis. Previous studies identified...
- 5From: Nature Reviews Cancer. (Vol. 10, Issue 10) Peer-ReviewedIn industrialized societies, cancer is second only to cardiovascular disease as a cause of death. The history of this disorder has the potential to improve our understanding of disease prevention, aetiology,...
- 6From: Nature Reviews Cancer. (Vol. 10, Issue 10) Peer-ReviewedThere is increasing evidence to suggest that the Parkinson's disease susceptibility genes are also associated with cancer. Indeed, patients with Parkinson's disease seem to have an increased risk of developing melanoma....
- 7From: Nature Reviews Cancer. (Vol. 10, Issue 10) Peer-ReviewedAlterations in chromatin dynamics are relevant to cancer initiation and progression. On page 669, Alea A. Mills discusses the polycomb and trithorax protein complexes that repress or promote gene expression,...
- 8From: Nature Reviews Cancer. (Vol. 10, Issue 10) Peer-ReviewedThe two most common types of liver cancer are hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC). Mouse models of liver cancer, based on either chemical induction or genetic engineering, usually reproduce HCC...
- 9From: Nature Reviews Cancer. (Vol. 10, Issue 10) Peer-ReviewedKaposi's sarcoma (KS) is the most common cancer in HIV-infected untreated individuals. Kaposi's sarcoma-associated herpesvirus (KSHV; also known as human herpesvirus 8 (HHV8)) is the infectious cause of this neoplasm....
- 10From: Nature Reviews Cancer. (Vol. 10, Issue 10) Peer-ReviewedXiong, S. et al. Cancer Res. 70, OF1-7 (2010) MDM4 is a protein involved in the negative regulation of the tumour suppressor p53 and is sometimes overexpressed in tumours that retain expression of wild-type p53....
- 11From: Nature Reviews Cancer. (Vol. 10, Issue 10) Peer-ReviewedEffective cytotoxic T cell (CTL) responses against tumours require the cross-presentation of tumour-derived antigens to tumour-specific CTLs by dendritic cells (DCs). However, the antigen presentation machinery of...
- 12From: Nature Reviews Cancer. (Vol. 10, Issue 10) Peer-ReviewedNiida, H. et al. EMBO J. 10 Sep 2010 (doi: 10.1038/emboj.2010.218) The checkpoint kinases CHK1 and CHK2 function in DNA damage response signalling to mediate cell cycle checkpoint arrest and DNA repair, and are...
- 13From: Nature Reviews Cancer. (Vol. 10, Issue 10) Peer-ReviewedThe discovery that cancer can be governed above and beyond the level of our DNA presents a new era for designing therapies that reverse the epigenetic state of a tumour cell. Understanding how altered chromatin dynamics...
- 14From: Nature Reviews Cancer. (Vol. 10, Issue 10) Peer-ReviewedAlthough the deregulation of micro-RNAs (miRNAs) has frequently been linked to tumorigenesis, the underlying molecular mechanisms responsible have been challenging to elucidate. Recent work reveals that oncogenic miRNAs...
- 15From: Nature Reviews Cancer. (Vol. 10, Issue 10) Peer-ReviewedThe RNA polymerase II (Pol II) elongation factor (ELL) was the first translocation partner of mixed lineage leukaemia (MLL) for which a biochemical function was determined. It was therefore proposed that the regulation...
- 16From: Nature Reviews Cancer. (Vol. 10, Issue 10) Peer-ReviewedPancreatic ductal adenocarcinoma (PDAC) is characterized by near-universal mutations in KRAS and frequent deregulation of crucial embryonic signalling pathways, including the Hedgehog (Hh) and Wnt-[beta]-catenin...
- 17From: Nature Reviews Cancer. (Vol. 10, Issue 10) Peer-ReviewedOnce upon a time, around 1,800 years ago, there was a Chinese medicine known as Huang Qin Tang. It was based on four different herbs and was used to treat gastrointestinal symptoms such as diarrhoea, nausea and...