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- 1From: Nature Reviews Genetics. (Vol. 10, Issue 10) Peer-ReviewedAt its inception, the cornerstone of newborn screening was the provision of direct medical benefit to the infant. Only serious health conditions with well-understood disease characteristics and symptoms that are amenable...
- 2From: Nature Reviews Genetics. (Vol. 10, Issue 10) Peer-ReviewedMany organisms are currently polyploid, or have a polyploid ancestry and now have secondarily 'diploidized' genomes. This finding is surprising because retained whole-genome duplications (WGDs) are exceedingly rare,...
- 3From: Nature Reviews Genetics. (Vol. 10, Issue 10) Peer-ReviewedDenver, D. R. et al. Proc. Natl Acad. Sci. USA 11 Sep 2009 (doi:10.1073/pnas.0904895106) This study has characterized the genome-wide rate and distribution of hundreds of base substitutions that have accumulated in the...
- 4From: Nature Reviews Genetics. (Vol. 10, Issue 10) Peer-ReviewedKellermann, V. etal. Science 325, 1244-1246 (2009) These authors show that Drosophila species that are distributed over a narrow habitat range are less genetically diverse than those species that live in more dispersed...
- 5From: Nature Reviews Genetics. (Vol. 10, Issue 10) Peer-ReviewedErrors in protein synthesis disrupt cellular fitness, cause disease phenotypes and shape gene and genome evolution. Experimental and theoretical results on this topic have accumulated rapidly in disparate fields, such as...
- 6From: Nature Reviews Genetics. (Vol. 10, Issue 10) Peer-ReviewedAuerbach, R. K. etal. Proc. Natl Acad. Sci. USA 106, 14926-14931 (2009) Dynamics and function of compact nucleosome arrays Poirier, M. G. etal. Nature Struct. Mol. Biol. 16, 938-944 (2009) These two papers use new...
- 7From: Nature Reviews Genetics. (Vol. 10, Issue 10) Peer-ReviewedIn their Ethics watch article (An offer you can't refuse? Ethical implications of non-invasive prenatal diagnosis. Nature Rev. Genet. 10, 515 (2009)) (1), Schmitz et al. argue that the implementation of noninvasive...
- 8From: Nature Reviews Genetics. (Vol. 10, Issue 10) Peer-ReviewedAlthough alterations in proto-oncogenes can explain their hyper-activation during tumorigenesis, oncogene overexpression can occur even in the absence of mutations at these loci. Christine Mayr and David Bartel now...
- 9From: Nature Reviews Genetics. (Vol. 10, Issue 10) Peer-ReviewedAdvances in sequencing technologies are primarily driven by the promise of medical genomics, which requires efficient and cost-effective sequencing. Stephen Quake and colleagues now show that single-molecule sequencing...
- 10From: Nature Reviews Genetics. (Vol. 10, Issue 10) Peer-ReviewedThe mammalian Y chromosome (chrY) has an unusual evolutionary history that has endowed it with similarly unusual features: the male-specific region (MSY), which does not ordinarily recombine with the X chromosome,...
- 11From: Nature Reviews Genetics. (Vol. 10, Issue 10) Peer-ReviewedTheir ability to move within genomes gives transposable elements an intrinsic propensity to affect genome evolution. Non-long terminal repeat (LTR) retrotransposons--including LINE-1, Aiu and SVA elements--have...
- 12From: Nature Reviews Genetics. (Vol. 10, Issue 10) Peer-ReviewedLambert, J.-C. et al. Nature Cenet. 6 Sep 2009 (doi:10.1038ing.439) Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease Harold, D. et al. Nature Genet. 6 Sep 2009...
- 13From: Nature Reviews Genetics. (Vol. 10, Issue 10) Peer-ReviewedIt is widely appreciated that transcription and chromatin structure are inextricably linked and that pre-mRNA processing is tightly coupled to transcription. A new dimension to these relationships has now emerged:...
- 14From: Nature Reviews Genetics. (Vol. 10, Issue 10) Peer-ReviewedWe agree with many of the comments on our Ethics watch article (An offer you can't refuse? Ethical implications of noninvasive prenatal diagnosis. Nature Rev. Genet. 10, 515 (2009)) (1) made by Ravitsky (Non-invasive...
- 15From: Nature Reviews Genetics. (Vol. 10, Issue 10) Peer-ReviewedHuman epigenome projects are hoped to generate new insights into how epigenetics contributes to disease and to provide new biomarkers and therapeutic targets. An understanding of normal epigenetic variation among and...
- 16From: Nature Reviews Genetics. (Vol. 10, Issue 10) Peer-ReviewedGuo, J. et al. Cell 10 Sep 2009 (doi:10.1016/j.cell.2009.06.043) Transcription-based negative-feedback loops are known to be essential in eukaryotic circadian oscillators; this study shows that a post-transcriptional...
- 17From: Nature Reviews Genetics. (Vol. 10, Issue 10) Peer-ReviewedOver the past year, induced pluripotent stem cells (iPSCs) have been created for several human disorders. However, the potential of this technology will only be realized once these cells can be used to inform the...
- 18From: Nature Reviews Genetics. (Vol. 10, Issue 10) Peer-ReviewedBayesian statistical methods have recently made great inroads into many areas of science, and this advance is now extending to the assessment of association between genetic variants and disease or other phenotypes. We...
- 19From: Nature Reviews Genetics. (Vol. 10, Issue 10) Peer-ReviewedUnderstanding how transposons contribute to genome diversity and evolution means investigating not only how they move but also which host mechanisms keep them in check. Two genome-wide studies have investigated the...
- 20From: Nature Reviews Genetics. (Vol. 10, Issue 10) Peer-ReviewedOver the past few years researchers have made substantial progress in the quest to create synthetic microorganisms, for which a necessary step is the transplantation of a synthetic genome into a bacterial cell. However,...