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- 1From: Nature Reviews Cardiology. (Vol. 10, Issue 1) Peer-ReviewedPostinfarction left ventricular remodelling commonly contorts the mitral valve, resulting in ischaemic mitral regurgitation (MR). Data from the Randomized Ischemic Mitral Evaluation now suggest that repairing the mitral...
- 2From: Nature Reviews Cardiology. (Vol. 10, Issue 1) Peer-ReviewedIn a large, new, observational study, [beta]-blocker treatment did not improve clinical outcomes in patients with coronary artery disease (CAD), including those with previous myocardial infarction, and was associated...
- 3From: Nature Reviews Cardiology. (Vol. 10, Issue 1) Peer-ReviewedAround 25-33% of patients with acute decompensated heart failure develop worsening kidney function, a condition referred to as acute cardiorenal syndrome (type 1). Diuretics are commonly used to treat persistent...
- 4From: Nature Reviews Cardiology. (Vol. 10, Issue 1) Peer-ReviewedAdding C-reactive protein (CRP) level to conventional cardiovascular risk models has been suggested to improve risk prediction for cardiovascular events. However, evaluation of the potential impact of CRP measurement in...
- 5From: Nature Reviews Cardiology. (Vol. 10, Issue 1) Peer-ReviewedMore than one in three US residents take multivitamin supplements, and approximately $5 billion is spent on vitamins in the USA alone. The findings from the largest randomized, double-blind, placebo-controlled study to...
- 6From: Nature Reviews Cardiology. (Vol. 10, Issue 1) Peer-ReviewedPrephlebotomy fasting is common practice when measuring blood lipid levels. Fasting was originally introduced to reduce variability between samples. A newly published study from Davinder Sidhu and Christopher Naugler...
- 7From: Nature Reviews Cardiology. (Vol. 10, Issue 1) Peer-ReviewedARCTIC and the TRILOGY ACS platelet function substudy, both presented as late-breaking clinical trials at the AHA 2012 Scientific Sessions, have called into question the utility of platelet-function testing. The...
- 8From: Nature Reviews Cardiology. (Vol. 10, Issue 1) Peer-ReviewedTwo phase I/II trials presented at the 2012 AHA Scientific Sessions and published in JAMA have shed new light on the effects of stem cell therapy in patients with myocardial infarction (MI). In the placebo-controlled...
- 9From: Nature Reviews Cardiology. (Vol. 10, Issue 1) Peer-ReviewedFibrinolysis is recommended in European and US guidelines for patients with ST- segment elevation myocardial infarction (STEMI) when a strategy of primary percutaneous coronary intervention (PPCI) is associated with...
- 10From: Nature Reviews Cardiology. (Vol. 10, Issue 1) Peer-ReviewedLow-dose aspirin reduces the risk of major vascular events after unprovoked venous thromboembolism (VTE), according to data from the ASPIRE trial, which were presented in November 2012 at the AHA Scientific Sessions....
- 11From: Nature Reviews Cardiology. (Vol. 10, Issue 1) Peer-ReviewedResearchers from Denmark have conducted the first multicentre comparison between first-line catheter ablation and antiarrhythmic drug therapy for paroxysmal atrial fibrillation (AF). The findings, published in the New...
- 12From: Nature Reviews Cardiology. (Vol. 10, Issue 1) Peer-ReviewedIntriguing findings from the RELAX-AHF trial of serelaxin (recombinant human relaxin 2; RLX030, Novartis, Basel, Switzerland) in patients with acute heart failure were presented by John Teerlink at the 2012 AHA...
- 13From: Nature Reviews Cardiology. (Vol. 10, Issue 1) Peer-ReviewedThe key feature defining transcatheter cardiovascular interventions is that access to the vessels and heart is achieved by arterial puncture with a needle, rather than surgical incision with a scalpel. However,...
- 14From: Nature Reviews Cardiology. (Vol. 10, Issue 1) Peer-ReviewedResuscitation guidelines and protocols for in-hospital cardiac arrest have changed in the past decade. Does this correlate with increased survival, and do the surviving patients retain neurological function? According...
- 15From: Nature Reviews Cardiology. (Vol. 10, Issue 1) Peer-ReviewedThe 2012 AHA Scientific Sessions saw considerable interest in the use of monoclonal antibodies against the serine protease PCSK9 (proprotein convertase subtilisin/kexin type 9) in patients with hypercholesterolaemia....
- 16From: Nature Reviews Cardiology. (Vol. 10, Issue 1) Peer-ReviewedNot all strategies for the management of chronic heart failure have been shown to be equally effective in improving outcomes, and the ideal programme has yet to be defined. The WHICH? trial sheds some light on whether a...
- 17From: Nature Reviews Cardiology. (Vol. 10, Issue 1) Peer-ReviewedThe appropriate functioning of implantable-cardioverter defibrillators (ICDs) can substantially reduce mortality, but the inappropriate discharge of these devices, for example triggered by supraventricular tachycardias,...
- 18From: Nature Reviews Cardiology. (Vol. 10, Issue 1) Peer-ReviewedFindings from the OPERA randomized trial suggest that perioperative consumption of fish oil, although safe and well-tolerated, does not reduce the incidence of postoperative atrial fibrillation (POAF). Data from the...
- 19From: Nature Reviews Cardiology. (Vol. 10, Issue 1) Peer-ReviewedThe syncytium of cardiomyocytes in the heart is tethered within a matrix composed principally of type I fibrillar collagen. The matrix has diverse mechanical functions that ensure the optimal contractile efficiency of...
- 20From: Nature Reviews Cardiology. (Vol. 10, Issue 1) Peer-ReviewedThe renin-angiotensin-aldosterone system (RAAS) regulates blood pressure through both direct and indirect mechanisms. RAAS blockers that act at the level of angiotensin or lower in the cascade can cause compensatory...