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- 1From: Nature Immunology. (Vol. 10, Issue 1) Peer-ReviewedThe cellular dynamics of the egress of lymphocytes from lymph nodes are poorly defined. Here we visualized the branched organization of lymph node cortical sinuses and found that after entry, some T cells were retained,...
- 2From: Nature Immunology. (Vol. 10, Issue 1) Peer-ReviewedA major challenge in vaccinology is to prospectively determine vaccine efficacy. Here we have used a systems biology approach to identify early gene 'signatures' that predicted immune responses in humans vaccinated with...
- 3From: Nature Immunology. (Vol. 10, Issue 1) Peer-ReviewedAnjana Rao recounts the contributions of two talented and productive postdoctoral fellows who purified and characterized the transcription factor NFAT. Given the vast amount of knowledge today about how...
- 4From: Nature Immunology. (Vol. 10, Issue 1) Peer-ReviewedThe mucosal immune system of the intestine is separated from a vast array of microbes by a single layer of epithelial cells. Cues from the commensal microflora are needed to maintain epithelial homeostasis, but the...
- 5From: Nature Immunology. (Vol. 10, Issue 1) Peer-ReviewedLeukocytes enter inflamed tissues by means of integrin activation and adhesion to the endothelium. In Science, Chavakis and colleagues identify the glycoprotein Del-1 as an endogenous inhibitor of the integrin LFA-1....
- 6From: Nature Immunology. (Vol. 10, Issue 1) Peer-ReviewedThe deaminase ADAR1 edits adenosines in nuclear transcripts of nervous tissue and is required in the fetal liver of the developing mouse embryo. Here we show by inducible gene disruption in mice that ADAR1 is essential...
- 7From: Nature Immunology. (Vol. 10, Issue 1) Peer-ReviewedHere we have identified a surface protein, TIGIT, containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif that was expressed on regulatory, memory and...
- 8From: Nature Immunology. (Vol. 10, Issue 1) Peer-ReviewedA systems biology approach provides correlates of successful vaccination, which allows a new method for measuring early vaccine efficiency and suggests hypotheses for the mechanisms that underlie immunogenicity....
- 9From: Nature Immunology. (Vol. 10, Issue 1) Peer-ReviewedThe human body contains over 500 individual lymph nodes, yet the biology of their formation is poorly understood. Here we identify human lymphoid tissue--inducer cells (LTi cells) as lineage-negative [RORC.sup.+]...
- 10From: Nature Immunology. (Vol. 10, Issue 1) Peer-ReviewedNew findings show that a subpopulation of mucosal [RORγt.sup.+] cells expresses natural killer cell receptors and produces interleukin 22. These innate immune cells may be pivotal in maintaining mucosal homeostasis....
- 11From: Nature Immunology. (Vol. 10, Issue 1) Peer-ReviewedVaccines for human and simian immunodeficiency virus (SIV) based on adenovirus serotype 5 (rAd5) vectors have thus far failed to induce protective immune responses. In Nature, Barouch and colleagues evaluate the...
- 12From: Nature Immunology. (Vol. 10, Issue 1) Peer-ReviewedT cell exhaustion often occurs during chronic infection and prevents optimal viral control. The molecular pathways involved in T cell exhaustion remain poorly understood. Here we show that exhausted [CD8.sup.+] T cells...
- 13From: Nature Immunology. (Vol. 10, Issue 1) Peer-ReviewedMany cell surface receptors signal through cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs). In Cell, Wucherpfennig and colleagues evaluate the functional relevance of membrane binding by ITAMs, a...
- 14From: Nature Immunology. (Vol. 10, Issue 1) Peer-ReviewedThe transcriptional regulator Aire mediates central tolerance mechanisms in the T cell lineage. In the Proceedings of the National Academy of Science, Lindh et al. show that Aire also serves a prominent function in...
- 15From: Nature Immunology. (Vol. 10, Issue 1) Peer-Reviewed[NKp46.sup.+][CD3.sup.-] natural killer lymphocytes isolated from blood, lymphoid organs, lung, liver and uterus can produce granule-dependent cytotoxicity and interferon-γ. Here we identify in dermis, gut lamina propria...
- 16From: Nature Immunology. (Vol. 10, Issue 1) Peer-ReviewedOn 24-27 September 2008, members of the scientific community gathered to discuss advances in innate immunity at the 'Toll meeting' in Cascais, Portugal. Before long, attendees noticed that 'Toll2008' might be a misnomer....
- 17From: Nature Immunology. (Vol. 10, Issue 1) Peer-ReviewedCalcium acts as a second messenger in many cell types, including lymphocytes. Resting lymphocytes maintain a low concentration of [Ca.sup.2+]. However, engagement of antigen receptors induces calcium influx from the...
- 18From: Nature Immunology. (Vol. 10, Issue 1) Peer-ReviewedIn the extraordinary and historic 2008 US presidential primary season leading up to the general election, the US role in international affairs--especially the war in Iraq--took center stage. As the general election...
- 19From: Nature Immunology. (Vol. 10, Issue 1) Peer-ReviewedRegulation of expression of the gene encoding interleukin 10 by the histone deacetylase HDAC11 emphasizes the ability of an antigen-presenting cell to induce immunity or tolerance in [CD4.sup.+] T cells Living...
- 20From: Nature Immunology. (Vol. 10, Issue 1) Peer-ReviewedAntigen-presenting cells (APCs) induce T cell activation as well as T cell tolerance. The molecular basis of the regulation of this critical 'decision' is not well understood. Here we show that HDAC11, a member of the...