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- 1From: Molecular Pain. (Vol. 10, Issue 1) Peer-ReviewedAuthor(s): Longchang Fan1,2 , Xiaowei Guan1 , Wei Wang1 , Jian-Yuan Zhao1 , Hongkang Zhang3 , Vinod Tiwari1 , Paul N Hoffman4 , Min Li3 and Yuan-Xiang Tao1,5 Peripheral nerve injury often causes persistent...
- 2From: Molecular Pain. (Vol. 10, Issue 1) Peer-ReviewedAuthor(s): Michiel Langeslag1 , Serena Quarta1 , Michael G Leitner2 , Michaela Kress1 and Norbert Mair1 Background The perception of pain is mediated by nociceptive primary afferent neurons that are excited upon...
- 3From: Molecular Pain. (Vol. 10, Issue 1) Peer-ReviewedBackground Cisplatin, a platinum-derived chemotherapeutic agent, produces antineoplastic effects coupled with toxic neuropathic pain and impaired general health status. These side-effects complicate long term studies...
- 4From: Molecular Pain. (Vol. 10, Issue 1) Peer-ReviewedAuthor(s): Kiran Kumar Bali1 , Michael Hackenberg2 , Avigail Lubin3 , Rohini Kuner1 and Marshall Devor3 Background Neuropathic pain phenotype varies greatly among individuals even when the underlying pathology is...
- 5From: Molecular Pain. (Vol. 10, Issue 1) Peer-ReviewedAuthor(s): Tsuyoshi Miyakawa1 , Yoshinori Terashima1 , Tsuneo Takebayashi1 , Katsumasa Tanimoto1 , Takehito Iwase1 , Izaya Ogon1 , Takeshi Kobayashi2 , Noritsugu Tohse2 and Toshihiko Yamashita1 Background Lumbar...
- 6From: Molecular Pain. (Vol. 10, Issue 1) Peer-ReviewedAuthor(s): Hiroki Hayashi1 , Masashi Iwata1 , Noboru Tsuchimori1 and Tatsumi Matsumoto1 Background Chronic pain is resistant to analgesics, and dramatically reduces the quality of life of patients. Non-steroidal...
- 7From: Molecular Pain. (Vol. 10, Issue 1) Peer-ReviewedAuthor(s): Daniela Maria Menichella1 , Belmadani Abdelhak2 , Dongjun Ren2 , Andrew Shum2 , Caroline Frietag2 and Richard J Miller2 Background Neuropathic pain in diabetes, Painful Diabetic Neuropathy (PDN), is a...
- 8From: Molecular Pain. (Vol. 10, Issue 1) Peer-ReviewedAuthor(s): Ellen Lund Schaldemose1 , Emilia Horjales-Araujo1 , Ditte Demontis2 , Anders D Barglum2 , Peter Svensson3,4 and Nanna Brix Finnerup1 Background Pain is a subjective experience that is influenced by a...
- 9From: Molecular Pain. (Vol. 10, Issue 1) Peer-ReviewedAuthor(s): Elizabeth J Rahn1,7 , Liting Deng2,3,4 , Ganesh A Thakur5 , Kiran Vemuri5 , Alexander M Zvonok5 , Yvonne Y Lai4 , Alexandros Makriyannis5 and Andrea G Hohmann1,2,3,4,6 Background Cannabinoids attenuate...
- 10From: Molecular Pain. (Vol. 10, Issue 1) Peer-ReviewedAuthor(s): Samridhi C Goswami1 , Danielle Thierry-Mieg2 , Jean Thierry-Mieg2 , Santosh Mishra3 , Mark A Hoon3 , Andrew J Mannes1 and Michael J Iadarola1 The concept of a specific circuit for the sensation of itch...
- 11From: Molecular Pain. (Vol. 10, Issue 1) Peer-ReviewedAuthor(s): Tie-Jun Sten Shi1,2,3 , Qiong Xiang1,2 , Ming-Dong Zhang1,4 , Swapnali Barde1 , Ylva Kai-Larsen1,4 , Kaj Fried1 , Anna Josephson1 , Laura Glück5 , Sergey M Deyev6 , Andrei V Zvyagin7 , Stefan Schulz5 and...
- 12From: Molecular Pain. (Vol. 10, Issue 1) Peer-ReviewedAuthor(s): Kathryn M Albers1,2 , Xiu Lin Zhang1,3 , Charlotte M Diges1,2 , Erica S Schwartz1,3 , Charles I Yang1,3 , Brian M Davis1,2 and Michael S Gold1,3 Background The prolonged release and activation of...
- 13From: Molecular Pain. (Vol. 10, Issue 1) Peer-ReviewedAuthor(s): Wei-Nan Chen1,2 , Cheng-Han Lee2 , Shing-Hong Lin1,2 , Chia-Wen Wong2 , Wei-Hsin Sun3 , John N Wood4 and Chih-Cheng Chen1,2,5 Background Chronic muscle pain is a significant clinical problem affecting...
- 14From: Molecular Pain. (Vol. 10, Issue 1) Peer-ReviewedBackground The measurement of mechanosensitivity is a key method for the study of pain in animal models. This is often accomplished with the use of von Frey filaments in an up-down testing paradigm. The up-down...
- 15From: Molecular Pain. (Vol. 10, Issue 1) Peer-ReviewedBackground Chronic Pancreatitis (CP) is a complex and multifactorial syndrome. Many contributing factors result in development of dysfunctional pain in a significant number of patients. Drugs developed to treat a...
- 16From: Molecular Pain. (Vol. 10, Issue 1) Peer-ReviewedAuthor(s): You-Qing Cai1 , Wei Wang1 , Yuan-Yuan Hou1 and Zhizhong Z Pan1 Background The rostral ventromedial medulla (RVM), consisting of the nucleus raphe magnus (NRM), nucleus reticularis gigantocellularis and...
- 17From: Molecular Pain. (Vol. 10, Issue 1) Peer-ReviewedInhibitory interneurons are an important component of dorsal horn circuitry where they serve to modulate spinal nociception. There is now considerable evidence indicating that reduced inhibition in the spinal dorsal...
- 18From: Molecular Pain. (Vol. 10, Issue 1) Peer-ReviewedAuthor(s): Maria Gutierrez-Mecinas1 , Masahiko Watanabe2 and Andrew J Todd1 Background Itch is an aversive sensation, distinct from pain, which is associated with the desire to scratch. Chronic itch is a common...
- 19From: Molecular Pain. (Vol. 10, Issue 1) Peer-ReviewedAuthor(s): Takashi Kurihara1,2 , Eri Sakurai2 , Masayasu Toyomoto3 , Isao Kii3 , Daisuke Kawamoto1 , Toshihide Asada1 , Tsutomu Tanabe2 , Megumu Yoshimura4 , Masatoshi Hagiwara3 and Atsuro Miyata1 Background...
- 20From: Molecular Pain. (Vol. 10, Issue 1) Peer-ReviewedAuthor(s): Soichiro Ide1,2 , Daisuke Nishizawa1 , Ken-ichi Fukuda3 , Shinya Kasai1 , Junko Hasegawa1 , Masakazu Hayashida4 , Masabumi Minami2 and Kazutaka Ikeda1 Extracellular adenosine 5'-triphosphate (ATP) has been...