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- 1From: Retrovirology. (Vol. 10) Peer-ReviewedBackground Human Immunodeficiency Virus Type I (HIV-1) infection is associated with a high incidence of B-cell lymphomas. The role of HIV in these lymphomas is unclear and currently there are no valid in vivo models...
- 2From: Retrovirology. (Vol. 10) Peer-ReviewedBackground Human T-cell leukemia virus type 1 (HTLV-1) causes chronic infection leading to development of adult T-cell leukemia (ATL) and inflammatory diseases. Non-human primates infected with simian T-cell leukemia...
- 3From: Retrovirology. (Vol. 10, Issue 1) Peer-ReviewedBackground Retroviral integrase catalyzes integration of viral DNA into the host genome. Integrase interactor (INI)1/hSNF5 is a host factor that binds to HIV-1 IN within the context of Gag-Pol and is specifically...
- 4From: Retrovirology. (Vol. 10, Issue 1) Peer-ReviewedBackground HIV-1 infection of target cells is mediated via the binding of the viral envelope protein, gp120, to the cell surface receptor CD4. This interaction leads to conformational rearrangements in gp120 forming...
- 5From: Retrovirology. (Vol. 10, Issue 1) Peer-ReviewedEstaquier et al. provide commentary on our paper that elucidated the mechanism by which HIV-1 causes cell death in activated CD4 T lymphocytes. We showed that proviral DNA integration triggers DNA-PK dependent death...
- 6From: Retrovirology. (Vol. 10, Issue 1) Peer-ReviewedBackground Human immunodeficiency virus type 1 (HIV-1) subtype C (C-HIV) is spreading rapidly and is now responsible for >50% of HIV-1 infections worldwide, and >95% of infections in southern Africa and central Asia....
- 7From: Retrovirology. (Vol. 10, Issue 1) Peer-ReviewedBackground HIV and SIV generally require CD4 binding prior to coreceptor engagement, but Env can acquire the ability to use CCR5 independently of CD4 under various circumstances. The ability to use CCR5 coupled with...
- 8From: Retrovirology. (Vol. 10, Issue 1) Peer-ReviewedBackground Following mucosal human immunodeficiency virus type 1 (HIV-1) transmission, type 1 interferons (IFNs) are rapidly induced at sites of initial virus replication in the mucosa and draining lymph nodes....
- 9From: Retrovirology. (Vol. 10, Issue 1) Peer-ReviewedSimian immunodeficiency virus (SIV) infection of Indian-origin rhesus macaques (RM) has been widely used as a well-established nonhuman primate (NHP) model for HIV/AIDS research. However, there have been a growing...
- 10From: Retrovirology. (Vol. 10, Issue 1) Peer-ReviewedBackground HIV-1 DNA is found both integrated in the host chromosome and unintegrated in various forms: linear (DNA.sub.L) or circular (1-LTRc, 2-LTRc or products of auto-integration). Here, based on pre-established...
- 11From: Retrovirology. (Vol. 10, Issue 1) Peer-ReviewedBackground HIV-1 replication can be successfully blocked by targeting gag gene products, offering a promising strategy for new drug classes that complement current HIV-1 treatment options. However, naturally...
- 12From: Retrovirology. (Vol. 10, Issue 1) Peer-ReviewedBackground International travel plays a role in the spread of HIV-1 across Europe. It is, however, not known whether international travel is more important for spread of the epidemic as compared to endogenous...
- 13From: Retrovirology. (Vol. 10, Issue 1) Peer-ReviewedBackground During reverse transcription, retroviruses duplicate the long terminal repeats (LTRs). These identical LTRs carry both promoter regions and functional polyadenylation sites. To express full-length...
- 14From: Retrovirology. (Vol. 10, Issue 1) Peer-Reviewed
TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm
Background Despite intensive investigation the mechanism by which HIV-1 reaches the host cell nucleus is unknown. TNPO3, a karyopherin mediating nuclear entry of SR-proteins, was shown to be required for HIV-1... - 15From: Retrovirology. (Vol. 10, Issue 1) Peer-ReviewedBackground HIV evolves rapidly at the epidemiological level but also at the within-host level. The virus' within-host evolutionary rates have been argued to be much higher than its between-host evolutionary rates....
- 16From: Retrovirology. (Vol. 10, Issue 1) Peer-ReviewedBackground Malignant human embryonal carcinoma cells (ECCs) rely on similar transcriptional networks as non-malignant embryonic stem cells (ESCs) to control selfrenewal, maintain pluripotency, and inhibit...
- 17From: Retrovirology. (Vol. 10, Issue 1) Peer-ReviewedAn HIV-1 infection progresses in most human individuals sooner or later into AIDS, a devastating disease that kills more than a million people worldwide on an annual basis. Nonetheless, certain HIV-1-infected persons...
- 18From: Retrovirology. (Vol. 10, Issue 1) Peer-ReviewedBackground Co-infection of HIV patients with cytomegalovirus (CMV) is associated with enhanced AIDS progression and CMV end-organ diseases. On the other hand, persistent CMV infection has recently been shown to...
- 19From: Retrovirology. (Vol. 10, Issue 1) Peer-ReviewedBackground Binding of HIV to the chemokine coreceptor CXCR4 mediates viral fusion and signal transduction that promotes actin dynamics critical for HIV infection of blood resting CD4 T cells. It has been suggested...
- 20From: Retrovirology. (Vol. 10, Issue 1) Peer-ReviewedCombination antiretroviral therapy, despite being potent and life-prolonging, is not curative and does not eradicate HIV-1 infection since interruption of treatment inevitably results in a rapid rebound of viremia....