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- 1From: BMC Medicine. (Vol. 10) Peer-ReviewedThe phosphatidylinositol 3-kinase (PI3K) pathway is commonly deregulated in cancer. In recent years, the results of the first phase I clinical trials with PI3K inhibitors have become available. In comparison to other...
- 2From: BMC Medicine. (Vol. 10) Peer-ReviewedBackground Inability to control autoimmunity is the primary barrier to developing a cure for type 1 diabetes (T1D). Evidence that human cord blood-derived multipotent stem cells (CB-SCs) can control autoimmune...
- 3From: BMC Medicine. (Vol. 10) Peer-ReviewedBackground Iron deficiency without anemia is related to adverse symptoms that can be relieved by supplementation. Since a blood donation can induce such an iron deficiency, we investigated the clinical impact of iron...
- 4From: BMC Medicine. (Vol. 10, Issue 1) Peer-ReviewedA meta-analytic review of the Triple P-Positive Parenting program by Wilson et al., recently published in BMC Medicine, claimed to demonstrate that although Triple P is widely disseminated and adopted, the evidence...
- 5From: BMC Medicine. (Vol. 10, Issue 1) Peer-ReviewedIn calcific tendinopathy (CT), calcium deposits in the substance of the tendon, with chronic activity-related pain, tenderness, localized edema and various degrees of decreased range of motion. CT is particularly common...
- 6From: BMC Medicine. (Vol. 10, Issue 1) Peer-ReviewedBackground The purpose, methods, data sources and assumptions behind the World Health Organization (WHO) Cervical Cancer Prevention and Control Costing (C4P) tool that was developed to assist low- and middle-income...
- 7From: BMC Medicine. (Vol. 10, Issue 1) Peer-ReviewedBackground Periprostatic (PP) adipose tissue surrounds the prostate, an organ with a high predisposition to become malignant. Frequently, growing prostatic tumor cells extend beyond the prostatic organ towards this...
- 8From: BMC Medicine. (Vol. 10, Issue 1) Peer-ReviewedThere is a plethora of published cancer biomarkers but the reality is that very few, if any, new circulating cancer biomarkers have entered the clinic in the last 30 years. I here try to explain this apparent oxymoron...
- 9From: BMC Medicine. (Vol. 10, Issue 1) Peer-ReviewedCardiovascular diseases and cancers are leading causes of morbidity and mortality. Reducing dietary saturated fat and replacing it with polyunsaturated fat is still the main dietary strategy to prevent cardiovascular...
- 10From: BMC Medicine. (Vol. 10, Issue 1) Peer-ReviewedBackground A season of birth effect in immune-mediated diseases (ID) such as multiple sclerosis and type 1 diabetes has been consistently reported. We aimed to investigate whether season of birth influences the risk...
- 11From: BMC Medicine. (Vol. 10, Issue 1) Peer-ReviewedBackground Studies have shown a correlation between bipolar disorder and diabetes mellitus. It is unclear if this correlation is a part of common pathophysiological pathways, or if medication for bipolar disorder has...
- 12From: BMC Medicine. (Vol. 10, Issue 1) Peer-ReviewedBackground N-acetyl cysteine (NAC) is a glutathione precursor that has been shown to have antidepressant efficacy in a placebo-controlled trial. The current study aimed to investigate the maintenance effects of NAC...
- 13From: BMC Medicine. (Vol. 10, Issue 1) Peer-ReviewedBackground Bevacizumab (BEV) plus triplet chemotherapy can increase efficacy of first-line treatment of metastatic colorectal cancer (MCRC), particularly integrated with secondary liver surgery in liver-limited (L-L)...
- 14From: BMC Medicine. (Vol. 10, Issue 1) Peer-ReviewedBackground Open access (OA) is a revolutionary way of providing access to the scholarly journal literature made possible by the Internet. The primary aim of this study was to measure the volume of scientific articles...
- 15From: BMC Medicine. (Vol. 10, Issue 1) Peer-ReviewedBackground We developed a Monte Carlo Markov model designed to investigate the effects of modifying cardiovascular disease (CVD) risk factors on the burden of CVD. Internal, predictive, and external validity of the...
- 16From: BMC Medicine. (Vol. 10, Issue 1) Peer-ReviewedBackground Lethal and edema toxins secreted by Bacillus anthracis during anthrax infection were found to incite serious cardiovascular complications. However, the underlying mechanisms in anthrax lethal toxin-induced...
- 17From: BMC Medicine. (Vol. 10, Issue 1) Peer-ReviewedNeurocognitive impairment is being increasingly recognized as an important issue in patients with cancer who develop cognitive difficulties either as part of direct or indirect involvement of the nervous system or as a...
- 18From: BMC Medicine. (Vol. 10, Issue 1) Peer-ReviewedType 2 diabetes mellitus is widely prevalent and is often coexistent with obesity. Many of the available treatment options have side effects such as weight gain which often affect patient's willingness to continue the...
- 19From: BMC Medicine. (Vol. 10, Issue 1) Peer-ReviewedBackground Lower limb injuries in sport are increasingly prevalent and responsible for large economic as well as personal burdens. In this review we seek to determine which easily implemented functional neuromuscular...
- 20From: BMC Medicine. (Vol. 10, Issue 1) Peer-ReviewedThe concepts of race and ethnicity are useful for understanding the distribution of disease in the population and for identifying at-risk groups for prevention and treatment efforts. The U.S. Department of Health and...