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- 1From: Nature Reviews Cancer. (Vol. 1, Issue 1) Peer-ReviewedPopulation-based studies have established that long-term intake of non-steroidal anti-inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic activity of cyclooxygenase (COX), reduces the relative risk for...
- 2From: Nature Reviews Cancer. (Vol. 1, Issue 1) Peer-ReviewedThe interactions between cancer cells and their micro- and macroenvironment create a context that promotes tumour growth and protects it from immune attack. The functional association of cancer cells with their...
- 3From: Nature Reviews Cancer. (Vol. 1, Issue 1) Peer-ReviewedAuthor(s): Emma Greenwood The INK4A/ARF locus codes for two, overlapping transcripts, INK4A and ARF , both of which are frequently mutated in human cancer. Knocking out either Arf or both gene products predisposes...
- 4From: Nature Reviews Cancer. (Vol. 1, Issue 1) Peer-ReviewedAuthor(s): Kristine Novak Vaccines and agents that target the tumour vasculature are two of the most attractive approaches to treating cancer. The heat-shock protein calreticulin (CRT) has been shown to combine the...
- 5From: Nature Reviews Cancer. (Vol. 1, Issue 1) Peer-ReviewedAuthor(s): Cath Brooksbank Most cancer researchers would agree that the distinction between an oncogene and a tumour suppressor is crystal clear: oncogenes are unleashed by dominant, gain-of-function mutations,...
- 6From: Nature Reviews Cancer. (Vol. 1, Issue 1) Peer-ReviewedEukaryotic cells can repair many types of DNA damage. Among the known DNA repair processes in humans, one type -- nucleotide excision repair (NER) -- specifically protects against mutations caused indirectly by...
- 7From: Nature Reviews Cancer. (Vol. 1, Issue 1) Peer-ReviewedAuthor(s): Cath Brooksbank We all know how tetchy we can be after skipping that vital cup of morning coffee; well, cancer cells can become addicted to stimulants, too. Two papers in the August 28 issue of Proceedings...
- 8From: Nature Reviews Cancer. (Vol. 1, Issue 1) Peer-ReviewedThe human genome has now been sequenced, a century after the re-discovery of Mendel's Laws, and the publication of Theodor Boveri's chromosomal theory of heredity. Tracing the historical landmarks of cancer genetics...
- 9From: Nature Reviews Cancer. (Vol. 1, Issue 1) Peer-ReviewedNatural killer cells, viruses and cancer. Cerwenka, A. & Lanier, L. L. Nature Reviews Immunology October (2001). With the ends in sight: images from the BRCA1 tumor suppressor. Baer, R. Nature Structural...
- 10From: Nature Reviews Cancer. (Vol. 1, Issue 1) Peer-ReviewedAuthor(s): Kristine Novak 5-fluorouracil (5-FU) has proved to be one of the most effective chemotherapeutics for colon cancer. It induces apoptosis in rapidly dividing cells, but little is known about the molecular...
- 11From: Nature Reviews Cancer. (Vol. 1, Issue 1) Peer-ReviewedAuthor(s): Sandra Clark One significant challenge in the field of cancer therapeutics is to find a way of overcoming cellular p53 inactivity. Reporting in the 30 August issue of Nature , Kenneth Raj and colleagues...
- 12From: Nature Reviews Cancer. (Vol. 1, Issue 1) Peer-ReviewedAuthor(s): Cath Brooksbank The molecular determinants of metastasis are one of the great unsolved mysteries of cancer research. But expression analysis using microarrays is exposing some of the daemons that lurk...
- 13From: Nature Reviews Cancer. (Vol. 1, Issue 1) Peer-ReviewedThe normal prostate and early-stage prostate cancers depend on androgens for growth and survival, and androgen ablation therapy causes them to regress. Cancers that are not cured by surgery eventually become androgen...
- 14From: Nature Reviews Cancer. (Vol. 1, Issue 1) Peer-ReviewedTherapeutics A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cells. Su, Z. et al . Proc. Natl Acad. Sci. USA 98 , 10332-10337 (2001) [PubMed] Pancreatic cancer...
- 15From: Nature Reviews Cancer. (Vol. 1, Issue 1) Peer-ReviewedColorectal cancer arises through a gradual series of histological changes, each of which is accompanied by a specific genetic alteration. In general, an intestinal cell needs to comply with two essential requirements to...
- 16From: Nature Reviews Cancer. (Vol. 1, Issue 1) Peer-ReviewedAuthor(s): Emma Greenwood RIZ1 -- a suspected protein methyltransferase -- has long been thought to possess tumour-suppressor activity: its gene maps to a region that is frequently deleted in human cancers, and...
- 17From: Nature Reviews Cancer. (Vol. 1, Issue 1) Peer-ReviewedBlocked drains Oesophageal cancer is a particularly insidious disease, and its incidence is rising in the developed world. It has usually begun to metastasize by the time it is diagnosed, and cure rates are low. If...
- 18From: Nature Reviews Cancer. (Vol. 1, Issue 1) Peer-ReviewedOne protein -- p53 -- plays nemesis to most cancers by condemning damaged cells to death or quarantining them for repair. But the activity of p53 relies on its intact native conformation, which can be lost following...
- 19From: Nature Reviews Cancer. (Vol. 1, Issue 1) Peer-ReviewedAuthor(s): Emma Greenwood The quest for immortality has long been pursued by humans -- as yet to no avail -- but it is also a critical step on the path to tumour formation, and cancer cells will use any means at...
- 20From: Nature Reviews Cancer. (Vol. 1, Issue 1) Peer-ReviewedTobacco is the world's single most avoidable cause of death. The World Health Organization has calculated that the 5.6 trillion cigarettes smoked per year at the close of the twentieth century will cause nearly 10...