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- 1From: Skeletal Muscle. (Vol. 1) Peer-ReviewedBackground Sarcopenia, the loss of skeletal muscle mass during aging, increases the risk for falls and dependency. Resistance exercise (RE) training is an effective treatment to improve muscle mass and strength in...
- 2From: Skeletal Muscle. (Vol. 1) Peer-ReviewedOculopharyngeal muscular dystrophy (OPMD) is a late-onset progressive muscle disorder caused by a poly-alanine expansion mutation in the Poly(A) Binding Protein Nuclear 1 (PABPN1). The molecular mechanisms that regulate...
- 3From: Skeletal Muscle. (Vol. 1) Peer-ReviewedBackground The most remarkable feature of skeletal muscle is the capacity to adapt its morphological, biochemical and molecular properties in response to several factors. Nonetheless, under pathological conditions,...
- 4From: Skeletal Muscle. (Vol. 1) Peer-ReviewedStromal interaction molecules (STIM) were identified as the endoplasmic-reticulum (ER) Ca.sup.2+ .sup.sensor controlling store-operated Ca.sup.2+ .sup.entry (SOCE) and Ca.sup.2+.sup.-release-activated Ca.sup.2+...
- 5From: Skeletal Muscle. (Vol. 1) Peer-ReviewedBackground A hallmark of muscular dystrophies is the replacement of muscle by connective tissue. Muscle biopsies from patients severely affected with facioscapulohumeral muscular dystrophy (FSHD) may contain few...
- 6From: Skeletal Muscle. (Vol. 1) Peer-ReviewedBackground Investigations into both the pathophysiology and therapeutic targets in muscle dystrophies have been hampered by the limited proliferative capacity of human myoblasts. Isolation of reliable and stable...
- 7From: Skeletal Muscle. (Vol. 1) Peer-ReviewedFukuyama-type congenital muscular dystrophy (FCMD) is a severe form of muscular dystrophy accompanied by abnormalities in the eye and brain. The incidence of FCMD is particularly high in the Japanese population....
- 8From: Skeletal Muscle. (Vol. 1) Peer-ReviewedAntisense oligonucleotides are short nucleic acids designed to bind to specific messenger RNAs in order to modulate splicing patterns or inhibit protein translation. As such, they represent promising therapeutic tools...
- 9From: Skeletal Muscle. (Vol. 1) Peer-ReviewedPeroxisome proliferator-activated receptors (PPARs) are a class of nuclear receptors that play important roles in development and energy metabolism. Whereas PPAR[delta] has been shown to regulate mitochondrial...
- 10From: Skeletal Muscle. (Vol. 1) Peer-ReviewedMutations in the [delta]-sarcoglycan gene cause limb-girdle muscular dystrophy 2F (LGMD2F), an autosomal recessive disease that causes progressive weakness and wasting of the proximal limb muscles and often has cardiac...
- 11From: Skeletal Muscle. (Vol. 1) Peer-ReviewedBackground Nemaline myopathy (NM) is a congenital muscle disease associated with weakness and the presence of nemaline bodies (rods) in muscle fibers. Mutations in seven genes have been associated with NM, but the...
- 12From: Skeletal Muscle. (Vol. 1) Peer-ReviewedBackground During development, the branchial mesoderm of Torpedo californica transdifferentiates into an electric organ capable of generating high voltage discharges to stun fish. The organ contains a high density of...
- 13From: Skeletal Muscle. (Vol. 1) Peer-ReviewedMuscular dystrophies are a large heterogeneous group of inherited diseases that cause progressive muscle weakness and permanent muscle damage. Very few muscular dystrophies show sufficient specific clinical features to...
- 14From: Skeletal Muscle. (Vol. 1) Peer-ReviewedBackground As the resident stem cells of skeletal muscle, satellite cells are activated by extracellular cues associated with local damage. Once activated, satellite cells will re-enter the cell cycle to proliferate...
- 15From: Skeletal Muscle. (Vol. 1) Peer-ReviewedMyogenesis is a complex and tightly regulated process, the end result of which is the formation of a multinucleated myofibre with contractile capability. Typically, this process is described as being regulated by a...
- 16From: Skeletal Muscle. (Vol. 1) Peer-ReviewedBackground Myogenic differentiation involves cell-cycle arrest, activation of the muscle-specific transcriptome, and elongation, alignment and fusion of myoblasts into multinucleated myotubes. This process is...
- 17From: Skeletal Muscle. (Vol. 1) Peer-ReviewedBackground Hundreds of genes, including muscle creatine kinase (MCK), are differentially expressed in fast- and slow-twitch muscle fibers, but the fiber type-specific regulatory mechanisms are not well understood....
- 18From: Skeletal Muscle. (Vol. 1) Peer-ReviewedBackground [gamma]-cytoplasmic ([gamma]-.sub.cyto ) actin levels are elevated in dystrophin-deficient mdx mouse skeletal muscle. The purpose of this study was to determine whether further elevation of...
- 19From: Skeletal Muscle. (Vol. 1) Peer-ReviewedCollagen VI myopathies, caused by mutations in the genes encoding collagen type VI (ColVI), represent a clinical continuum with Ullrich congenital muscular dystrophy (UCMD) and Bethlem myopathy (BM) at each end of the...
- 20From: Skeletal Muscle. (Vol. 1) Peer-ReviewedAuthors: David J Glass (corresponding author) (equal contributor) [1]; Kevin P Campbell (equal contributor) [2]; Michael A Rudnicki (equal contributor) [3] Over the past decade or two, cellular signaling and...