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- 1From: Silence. (Vol. 1) Peer-ReviewedFire and Mello initiated the current explosion of interest in RNA interference (RNAi) biology with their seminal work in Caenorhabditis elegans. These observations were closely followed by the demonstration of RNAi in...
- 2From: Silence. (Vol. 1) Peer-ReviewedEarlier this year plant scientists met in Santa Fe, New Mexico at the Keystone Symposium "RNA Silencing Mechanisms in Plants". Sessions included small RNA biogenesis and signalling, development and stress responses,...
- 3From: Silence. (Vol. 1) Peer-ReviewedBackground MicroRNAs (miRNA) are an abundant and ubiquitous class of small RNAs that play prominent roles in gene regulation. A significant fraction of miRNA genes reside in the introns of the host genes in the same...
- 4From: Silence. (Vol. 1) Peer-ReviewedBackground Micro(mi)RNAs are short RNA sequences, ranging from 16 to 35 nucleotides (miRBase; http://www.mirbase.org). The majority of the identified sequences are 21 or 22 nucleotides in length. Despite the range of...
- 5From: Silence. (Vol. 1) Peer-ReviewedBackground While increasing numbers of small interfering RNA (siRNA) therapeutics enter into clinical trials, the quantification of siRNA from clinical samples for pharmacokinetic studies remains a challenge. This...
- 6From: Silence. (Vol. 1) Peer-ReviewedARGONAUTE1 (AGO1) mediates microRNA- and small interfering RNA-directed posttranscriptional gene silencing in Arabidopsis thaliana. Mutant alleles of SQUINT (SQN) slightly reduce AGO1 activity and have weak effects on...
- 7From: Silence. (Vol. 1) Peer-ReviewedBackground Drosha is a nuclear RNase III enzyme that initiates processing of regulatory microRNA. Together with partner protein DiGeorge syndrome critical region 8 (DGCR8), it forms the Microprocessor complex, which...
- 8From: Silence. (Vol. 1) Peer-ReviewedArgonaute is the principal protein component of the mechanisms of RNA silencing, providing anchor sites for the small guide RNA strand and the 'slicer' activity for cleavage of target mRNAs or short passenger RNA...
- 9From: Silence. (Vol. 1) Peer-ReviewedAuthors: David C Baulcombe (equal contributor) [1]; Phillip D Zamore (corresponding author) (equal contributor) [1] Editorial Welcome to Silence [1], a new open-access journal devoted to RNA silencing and other...
- 10From: Silence. (Vol. 1) Peer-ReviewedThis potent ability of small interfering (si)RNAs to inhibit the expression of complementary RNA transcripts is being exploited as a new class of therapeutics for a variety of diseases. However, the efficient and safe...
- 11From: Silence. (Vol. 1) Peer-ReviewedBackground Breast milk is a complex liquid that provides nutrition to the infant and facilitates the maturation of the infant's immune system. Recent studies indicated that microRNA (miRNA) exists in human body...
- 12From: Silence. (Vol. 1) Peer-ReviewedThe recent symposium, RNA silencing: Mechanism, Biology and Applications, organized by Phillip D. Zamore (University of Massachusetts Medical School) and Beverly Davidson (University of Iowa), and held in Keystone,...
- 13From: Silence. (Vol. 1) Peer-ReviewedBackground Antisense reagents can serve as efficient and versatile tools for studying gene function by inhibiting nucleic acids in vivo. Antisense reagents have particular utility for the experimental manipulation of...
- 14From: Silence. (Vol. 1) Peer-Reviewed
- 15From: Silence. (Vol. 1) Peer-ReviewedBackground Micro(mi)RNAs regulate gene expression through translational attenuation and messenger (m)RNA degradation, and are associated with differentiation, homeostasis and disease. Natural miRNA target recognition...
- 16From: Silence. (Vol. 1) Peer-ReviewedMicro(mi)RNAs regulate gene expression by what are believed to be related but separate mechanistic processes. The relative contribution that each process plays, their mechanistic overlap, and the degree by which they...
- 17From: Silence. (Vol. 1) Peer-ReviewedBackground MicroRNAs are a class of small noncoding RNAs that are abnormally expressed in different cancer cells. Molecular signature of miRNAs in different malignancies suggests that these are not only actively...