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- 1From: Genome Medicine. (Vol. 1, Issue 11) Peer-ReviewedAuthor(s): Aislyn D Wist1 , Seth I Berger1 and Ravi Iyengar1 Our knowledge of the mechanisms by which drugs act physiologically advanced radically during the twentieth century. With the advent of biochemistry and...
- 2From: Genome Medicine. (Vol. 1, Issue 77) Peer-ReviewedAuthor(s): Nicki Tiffin1 , Miguel A Andrade-Navarro2 and Carolina Perez-Iratxeta3 Historically, disease phenotype has informed the selection of candidate disease genes through observations of the effects of...
- 3From: Genome Medicine. (Vol. 1, Issue 89) Peer-ReviewedAuthor(s): Eleanor Wong1 and Chia-Lin Wei1,2 Now that the complete human genome sequence is available [1], the current challenges are to identify all the functional genetic elements it encodes and to elucidate the...
- 4From: Genome Medicine. (Vol. 1, Issue 101) Peer-ReviewedAuthor(s): Victoria P Belancio2 , Prescott L Deininger1 and Astrid M Roy-Engel1 Introduction to mammalian transposable elements Transposable elements (TEs) occupy almost half, 46%, of the human genome, making the...
- 5From: Genome Medicine. (Vol. 1, Issue 30) Peer-ReviewedAuthor(s): David G Nathan1 and Stuart H Orkin1 Now that the Obama administration has begun to reshape and restore the government, the editors of Genome Medicine have asked our opinions on the future of biomedical...
- 6From: Genome Medicine. (Vol. 1, Issue 37) Peer-ReviewedAuthor(s): Nora B Henrikson1,2 , Deborah Bowen3 and Wylie Burke2,4 For families with rare, highly penetrant genetic conditions, genome medicine is already a reality, with genetic tests that can identify the family...
- 7From: Genome Medicine. (Vol. 1, Issue 63) Peer-ReviewedPrion diseases share common features of neurodegenerative disorders, infectious diseases and pathologies linked to misfolded proteins. Whether these aspects are independently and fortuitously present in prion diseases...
- 8From: Genome Medicine. (Vol. 1, Issue 70) Peer-ReviewedAlthough most stem cell therapy has been non-controversial, therapy based on pluripotent stem cells has raised both ethical and safety concerns. Despite these concerns, the use of cells derived from pluripotent stem...
- 9From: Genome Medicine. (Vol. 1, Issue 32) Peer-ReviewedFunctional genomic studies are dominated by transcriptomic approaches, in part reflecting the vast amount of information that can be obtained, the ability to amplify mRNA and the availability of commercially...
- 10From: Genome Medicine. (Vol. 1, Issue 50) Peer-ReviewedA large amount of experimental data collected over the last decade has shown that genomic organization is very complex and has highlighted the fact that the current set of gene annotations does not fully capture this...
- 11From: Genome Medicine. (Vol. 1, Issue 85) Peer-ReviewedAuthor(s): Chunxiang Zhang1 It is well established that the transition of vascular smooth muscle cells (VSMCs) from a differentiated phenotype to a dedifferentiated state plays a critical role in the pathogenesis of...
- 12From: Genome Medicine. (Vol. 1, Issue 104) Peer-ReviewedAuthor(s): Michael V Holmes1 , Sonia H Shah2 , Aspasia Angelakopoulou3 , Tauseef Khan3 , Daniel Swerdlow1 , Karoline Kuchenbaecker1 , Reecha Sofat4 and Tina Shah4 Complex disease genetics is at a critical turning...
- 13From: Genome Medicine. (Vol. 1, Issue 78) Peer-ReviewedAuthor(s): George A Calin1 The organizers of the 2009 Keystone Symposia on MicroRNAs and Cancer assembled a fine panel of speakers, and the audience of more than 300 participants consisted mainly of young scientists,...
- 14From: Genome Medicine. (Vol. 1, Issue 23) Peer-ReviewedAuthor(s): Nicholas Katsanis1 The sequencing of several genomes and the HapMap project, coupled to high-density genotyping technologies and new statistical tools, have made possible the systematic interrogation of...
- 15From: Genome Medicine. (Vol. 1, Issue 113) Peer-ReviewedAuthor(s): Alice M Wood1 , See Ling Tan2 and Robert A Stockley3 Chronic obstructive pulmonary disease (COPD) is characterized by airflow obstruction, together with an abnormal inflammatory response to noxious...
- 16From: Genome Medicine. (Vol. 1, Issue 106) Peer-ReviewedDNA methylation of promoter CpG islands is strongly associated with gene silencing and is known as a frequent cause of loss of expression of tumor suppressor genes, as well as other genes involved in tumor formation....
- 17From: Genome Medicine. (Vol. 1, Issue 118) Peer-ReviewedPublic health preparedness requires effective surveillance of and rapid response to infectious disease outbreaks. Inclusion of research activities within the outbreak setting provides important opportunities to maximize...
- 18From: Genome Medicine. (Vol. 1, Issue 21) Peer-ReviewedA report of the 1st GOLDEN HELIX Symposium 'Copy number variation and genomic alterations in health and disease', Athens, Greece, 28-29 November 2008. Author(s): George P Patrinos1,2 and Michael B Petersen3 The...
- 19From: Genome Medicine. (Vol. 1, Issue 29) Peer-ReviewedAuthor(s): Charles Auffray1 Advances in biological and medical research and their translation into diagnostic, prognostic and therapeutic tools are relying increasingly on partnerships between the academic...
- 20From: Genome Medicine. (Vol. 1, Issue 90) Peer-ReviewedAuthor(s): Harry Campbell1 , Igor Rudan1,2 , Alan H Bittles3 and Alan F Wright4 The demographic structure of human populations has changed dramatically over the last 200 years, resulting in major changes in the size...