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- 1From: Acta Neuropathologica Communications. (Vol. 1, Issue 1) Peer-ReviewedBackground Inclusion body myositis (IBM) is a slowly progressive inflammatory myopathy of the elderly that does not show significant clinical improvement in response to steroid therapy. Distinguishing IBM from...
- 2From: Acta Neuropathologica Communications. (Vol. 1, Issue 1) Peer-ReviewedBackground Alzheimer's disease (AD) is characterized by the deposition of insoluble amyloid plaques in the neuropil composed of highly stable, self-assembled Amyloid-beta (A[beta]) fibrils. Copper has been implicated...
- 3From: Acta Neuropathologica Communications. (Vol. 1, Issue 1) Peer-ReviewedBackground Environmental toxins are suspected to play a role in the pathogenesis of amyotrophic lateral sclerosis (ALS). In an attempt to determine which pathways these toxins can use to enter motor neurons we...
- 4From: Acta Neuropathologica Communications. (Vol. 1, Issue 1) Peer-ReviewedBackground The causes of sporadic amyotrophic lateral sclerosis (SALS) and other types of motor neuron disease (MND) remain largely unknown. Heavy metals have long been implicated in MND, and it has recently been...
- 5From: Acta Neuropathologica Communications. (Vol. 1, Issue 1) Peer-ReviewedBackground Human prion diseases are a group of rare fatal neurodegenerative conditions with well-developed clinical and neuropathological diagnostic criteria. Recent observations have expanded the spectrum of prion...
- 6From: Acta Neuropathologica Communications. (Vol. 1, Issue 1) Peer-ReviewedBackground The amyloid hypothesis in Alzheimer disease (AD) considers amyloid [beta] peptide (A[beta]) deposition causative in triggering down-stream events like neurofibrillary tangles, cell loss, vascular damage...
- 7From: Acta Neuropathologica Communications. (Vol. 1, Issue 1) Peer-ReviewedBackground In some prion diseases, misfolded aggregated protease-resistant prion protein (PrPres) is found in brain as amyloid, which can cause cerebral amyloid angiopathy. Small diffusible precursors of PrPres...
- 8From: Acta Neuropathologica Communications. (Vol. 1, Issue 1) Peer-ReviewedBackground Alzheimer's disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) plaques, intracellular hyperphosphorylated tau, progressive synaptic alterations, axonal...
- 9From: Acta Neuropathologica Communications. (Vol. 1, Issue 1) Peer-ReviewedBackground A reduction in peripheral nervous system (PNS) insulin signaling is a proposed mechanism that may contribute to sensory neuron dysfunction and diabetic neuropathy. Neuronal insulin resistance is associated...
- 10From: Acta Neuropathologica Communications. (Vol. 1, Issue 1) Peer-ReviewedParkinson's disease (PD) is a progressive neurodegenerative disorder typified by the presence of intraneuronal inclusions containing aggregated alpha synuclein ([alpha]syn). The progression of parkinsonian pathology and...
- 11From: Acta Neuropathologica Communications. (Vol. 1, Issue 1) Peer-ReviewedBackground Autopsy series commonly report a high percentage of coincident pathologies in demented patients, including patients with a clinical diagnosis of dementia of the Alzheimer type (DAT). However many clinical...
- 12From: Acta Neuropathologica Communications. (Vol. 1, Issue 1) Peer-ReviewedBackground Our aim was to develop a new protocol for MGMT immunohistochemistry with good agreement between observers and good correlation with molecular genetic tests of tumour methylation. We examined 40 primary...
- 13From: Acta Neuropathologica Communications. (Vol. 1, Issue 1) Peer-ReviewedBackground Protein aggregation and the formation of intracellular inclusions are a central feature of many neurodegenerative disorders, but precise knowledge about their pathogenic role is lacking in most instances....
- 14From: Acta Neuropathologica Communications. (Vol. 1, Issue 1) Peer-ReviewedBackground Aberrant neuron/glia interactions can contribute to a variety of neurodegenerative diseases and we have previously demonstrated that enhanced activation of Erb B2, which is a member of the epidermal growth...
- 15From: Acta Neuropathologica Communications. (Vol. 1, Issue 1) Peer-ReviewedMonosomy 1p36 is the most common subtelomeric chromosomal deletion linked to mental retardation and seizures. Neuroimaging studies suggest that monosomy 1p36 is associated with brain malformations including...
- 16From: Acta Neuropathologica Communications. (Vol. 1, Issue 1) Peer-ReviewedBackground The Arctic mutation (p.E693G/p.E22G)fs within the [beta]-amyloid (A[beta]) region of the [beta]-amyloid precursor protein gene causes an autosomal dominant disease with clinical picture of typical...
- 17From: Acta Neuropathologica Communications. (Vol. 1, Issue 1) Peer-ReviewedBackground Pilocytic astrocytomas occur predominantly in childhood. In contrast to the posterior fossa location, hypothalamo-chiasmatic pilocytic astrocytomas display a worse prognosis often leading to multiple...
- 18From: Acta Neuropathologica Communications. (Vol. 1, Issue 1) Peer-ReviewedBackground Medulloblastoma is a leading cause of childhood cancer-related deaths. Current aggressive treatments frequently lead to cognitive and neurological disabilities in survivors. Novel targeted therapies are...
- 19From: Acta Neuropathologica Communications. (Vol. 1, Issue 1) Peer-ReviewedBackground Neuron Glial 2 (NG2) cells are glial cells known to serve as oligodendrocyte progenitors as well as modulators of the neuronal network. Altered NG2 cell morphology and up-regulation as well as increased...
- 20From: Acta Neuropathologica Communications. (Vol. 1, Issue 1) Peer-ReviewedBackground Focal cortical dysplasias (FCD) are local disturbances of neocortical architecture and a common cause of pharmaco-resistant focal epilepsy. Little is known about the pathomechanisms leading to...