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- 1From: Cancer and Metastasis Reviews. (Vol. 30, Issue 3-4) Peer-Reviewed15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a key prostaglandin catabolic enzyme catalyzing the oxidation and inactivation of prostaglandin E.sub.2 (PGE.sub.2) synthesized from the cyclooxygenase (COX) pathway....