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- 1From: Cancer and Metastasis Reviews. (Vol. 33, Issue 2-3) Peer-ReviewedThere is a need in prostate cancer diagnostics and research for a label-free imaging methodology that is nondestructive, rapid, objective, and uninfluenced by water. Raman spectroscopy provides a molecular signature,...
- 2From: Cancer and Metastasis Reviews. (Vol. 31, Issue 3-4) Peer-ReviewedRaf kinase inhibitory protein (RKIP) was initially identified as phosphatidylethanolamine binding protein in bovine brain. It was later identified as a protein that inhibits Raf kinase activation of MEK. Further...
- 3From: Cancer and Metastasis Reviews. (Vol. 35, Issue 2) Peer-ReviewedThe advent of next-generation sequencing methods is fuelling the discovery of multiple non-coding RNA transcripts with direct implication in cell biology and homeostasis. This new layer of biological regulation seems to...
- 4From: Cancer and Metastasis Reviews. (Vol. 41, Issue 2) Peer-ReviewedCancer, especially when it has metastasized to different locations in the body, is notoriously difficult to treat. Metastatic cancer accounts for most cancer deaths and thus remains an enormous challenge. During the...
- 5From: Cancer and Metastasis Reviews. (Vol. 41, Issue 2) Peer-ReviewedAuthor(s): Massimiliano Agostini 1, Gerry Melino 1, Bola Habeb 2, Jorgelina M. Calandria 2, Nicolas G. Bazan 2 Author Affiliations: (1) grid.6530.0, 0000 0001 2300 0941, Department of Experimental Medicine, TOR,...
- 6From: Cancer and Metastasis Reviews. (Vol. 29, Issue 2) Peer-ReviewedInflammation has been suggested to represent the seventh hallmark of cancer. Myelomonocytic cells are a key component of cancer-related inflammation. Tumor-associated macrophages and their mediators affect key elements...
- 7From: Cancer and Metastasis Reviews. (Vol. 30, Issue 1) Peer-ReviewedUntil now, the anatomic extent of tumor (TNM classification) has been by far the most important factor to predict the prognosis of colorectal cancer patients. However, in recent years, data collected from large cohorts...
- 8From: Cancer and Metastasis Reviews. (Vol. 39, Issue 4) Peer-ReviewedAs a member of small GTPase family, KRAS protein is a key physiological modulator of various cellular activities including proliferation. However, mutations of KRAS present in numerous cancer types, most frequently in...
- 9From: Cancer and Metastasis Reviews. (Vol. 29, Issue 4) Peer-ReviewedBreast cancer is the most common malignancy with the highest incidence among women in the world. Metastasis is the major reason for breast cancer-related deaths. The precise molecular circuitry that governs the...
- 10From: Cancer and Metastasis Reviews. (Vol. 31, Issue 1-2) Peer-ReviewedIn order to metastasize, cancer cells must first detach from the primary tumor, migrate, invade through tissues, and attach to a second site. Hakai was discovered as an E3 ubiquitin-ligase that mediates the...
- 11From: Cancer and Metastasis Reviews. (Vol. 29, Issue 3) Peer-ReviewedAlmost 25 centuries ago, Hippocrates, the father of medicine, proclaimed "Let food be thy medicine and medicine be thy food." Exploring the association between diet and health continues today. For example, we now know...
- 12From: Cancer and Metastasis Reviews. (Vol. 32, Issue 1-2) Peer-ReviewedThe complicity of centrosomes in carcinogenesis is unmistakable. Mounting evidence clearly implicates a robust correlation between centrosome amplification (CA) and malignant transformation in diverse tissue types....
- 13From: Cancer and Metastasis Reviews. (Vol. 34, Issue 1) Peer-ReviewedClinical outcomes, such as recurrence-free survival and overall survival, in ovarian cancer are quite variable, independent of common characteristics such as stage, response to therapy, and grade. This disparity in...
- 14From: Cancer and Metastasis Reviews. (Vol. 37, Issue 4) Peer-ReviewedMitochondrial DNA (mtDNA) encodes for only a fraction of the proteins that are encoded within the nucleus, and therefore has typically been regarded as a lesser player in cancer biology and metastasis. Accumulating...
- 15From: Cancer and Metastasis Reviews. (Vol. 38, Issue 1-2) Peer-ReviewedMetabolism is a continuous source of acids. To keep up with a desired metabolic rate, tumors must establish an adequate means of clearing their acidic end-products. This homeostatic priority is achieved by various...
- 16From: Cancer and Metastasis Reviews. (Vol. 30, Issue 2) Peer-ReviewedAuthor(s): Mariacristina Chioda 1, Elisa Peranzoni 1, Giacomo Desantis 2 3, Francesca Papalini 2 3, Erika Falisi 1 2, Samantha Solito 2, Susanna Mandruzzato 1 2, Vincenzo Bronte 1 Author Affiliations: (1)...
- 17From: Cancer and Metastasis Reviews. (Vol. 30, Issue 3-4) Peer-ReviewedPolyunsaturated fatty acids (PUFA) play important roles in the normal physiology and in pathological states including inflammation and cancer. While much is known about the biosynthesis and biological activities of...
- 18From: Cancer and Metastasis Reviews. (Vol. 39, Issue 3) Peer-ReviewedProgression through dissemination to tumor-surrounding tissues and metastasis development is a hallmark of cancer that requires continuous cell-to-cell interactions and tissue remodeling. In fact, metastization can be...
- 19From: Cancer and Metastasis Reviews. (Vol. 36, Issue 1) Peer-ReviewedAuthor(s): Ulrich Pfeffer 1, Paola Queirolo 2 Author Affiliations: (1) grid.410345.7, Department of Integrated Oncology Therapies, Laboratory of Molecular Pathology, IRCCS AOU San Martino - IST Istituto Nazionale per...
- 20From: Cancer and Metastasis Reviews. (Vol. 34, Issue 2) Peer-ReviewedLung cancer is the leading cause of cancer-related deaths worldwide. The initiation and progression of lung cancer is the result of the interaction between permanent genetic and dynamic epigenetic alterations. DNA...